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Genome-wide associa...
Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.
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Johnson, David C (author)
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Weinhold, Niels (author)
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Mitchell, Jonathan S (author)
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Chen, Bowang (author)
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Kaiser, Martin (author)
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Begum, Dil B (author)
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Hillengass, Jens (author)
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Bertsch, Uta (author)
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Gregory, Walter A (author)
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Cairns, David (author)
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Jackson, Graham H (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Nickel, Jolanta (author)
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Hoffmann, Per (author)
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Nöethen, Markus M (author)
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Stephens, Owen W (author)
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Barlogie, Bart (author)
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Davis, Faith E (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Goldschmidt, Hartmut (author)
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Houlston, Richard S (author)
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Morgan, Gareth J (author)
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(creator_code:org_t)
- 2016-01-08
- 2016
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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http://dx.doi.org/10... (free)
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Abstract
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- Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancestry, totalling 3,256 patients with 1,200 MM-associated deaths. Each series is genotyped for ∼600,000 single nucleotide polymorphisms across the genome; genotypes for six million common variants are imputed using 1000 Genomes Project and UK10K as the reference. The association between genotype and OS is assessed by Cox proportional hazards model adjusting for age, sex, International staging system and treatment. We identify a locus at 6q25.1 marked by rs12374648 associated with MM-OS (hazard ratio=1.34, 95% confidence interval=1.22-1.48, P=4.69 × 10(-9)). Our findings have potential clinical implications since they demonstrate that inherited genotypes can provide prognostic information in addition to conventional tumor acquired prognostic factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Johnson, David C
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Weinhold, Niels
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Mitchell, Jonath ...
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Chen, Bowang
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Kaiser, Martin
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Begum, Dil B
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show more...
-
Hillengass, Jens
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Bertsch, Uta
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Gregory, Walter ...
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Cairns, David
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Jackson, Graham ...
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Försti, Asta
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Nickel, Jolanta
-
Hoffmann, Per
-
Nöethen, Markus ...
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Stephens, Owen W
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Barlogie, Bart
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Davis, Faith E
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Hemminki, Kari
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Goldschmidt, Har ...
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Houlston, Richar ...
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Morgan, Gareth J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University