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  • Johnson, David C (author)

Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-01-08
  • Springer Science and Business Media LLC,2016

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5cee2449-2fa1-4a33-ae00-a7506be11a75
  • https://lup.lub.lu.se/record/8592697URI
  • https://doi.org/10.1038/ncomms10290DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Survival following a diagnosis of multiple myeloma (MM) varies between patients and some of these differences may be a consequence of inherited genetic variation. In this study, to identify genetic markers associated with MM overall survival (MM-OS), we conduct a meta-analysis of four patient series of European ancestry, totalling 3,256 patients with 1,200 MM-associated deaths. Each series is genotyped for ∼600,000 single nucleotide polymorphisms across the genome; genotypes for six million common variants are imputed using 1000 Genomes Project and UK10K as the reference. The association between genotype and OS is assessed by Cox proportional hazards model adjusting for age, sex, International staging system and treatment. We identify a locus at 6q25.1 marked by rs12374648 associated with MM-OS (hazard ratio=1.34, 95% confidence interval=1.22-1.48, P=4.69 × 10(-9)). Our findings have potential clinical implications since they demonstrate that inherited genotypes can provide prognostic information in addition to conventional tumor acquired prognostic factors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Weinhold, Niels (author)
  • Mitchell, Jonathan S (author)
  • Chen, Bowang (author)
  • Kaiser, Martin (author)
  • Begum, Dil B (author)
  • Hillengass, Jens (author)
  • Bertsch, Uta (author)
  • Gregory, Walter A (author)
  • Cairns, David (author)
  • Jackson, Graham H (author)
  • Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-asf (author)
  • Nickel, Jolanta (author)
  • Hoffmann, Per (author)
  • Nöethen, Markus M (author)
  • Stephens, Owen W (author)
  • Barlogie, Bart (author)
  • Davis, Faith E (author)
  • Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk (author)
  • Goldschmidt, Hartmut (author)
  • Houlston, Richard S (author)
  • Morgan, Gareth J (author)
  • Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC72041-1723

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