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Cytotoxicity and ap...
Cytotoxicity and apoptotic effects of microcystin-LR and anatoxin-a in mouse lymphocytes
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Teneva, I (author)
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Mladenov, R (author)
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Popov, N (author)
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- Dzhambazov, Balik (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Folia Biologica. - 0015-5500. ; 51:3, s. 62-67
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http://fb.cuni.cz/Da... (free)
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Abstract
Subject headings
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- There is an increasing amount of knowledge on the cytotoxic properties of cyanotoxins, but relatively little is known regarding their fine specificity and mechanisms of action. In this study, we investigated the influence of microcystin-LR and AnTx-a on mouse B- and T-lymphocyte subpopulations in vitro. Cyanotoxins significantly decreased the cell viability after 4 and 24 h, compared to the untreated control. After 24 h exposure to microcystin-LR and anatoxin-a, the viability of splenocytes dropped to 23% and 57%, respectively. Our data demonstrate that microcystin-LR induced apoptosis specifically in mouse B cells, probably via the B-cell antigen receptor and mitochondrial pathway, while the T cells were not affected. AnTx-a showed cytotoxic effects on both lymphocyte subpopulations, but the effects were driven by mechanisms different from apoptosis. These findings demonstrate that the cyanotoxins could cause cytotoxic alterations in a variety of cell types different from the major targets, operating via distinct mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- cytotoxicity
- microcystin-LR
- anatoxin-a
- mouse lymphocytes
- apoptosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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