Search: onr:"swepub:oai:lup.lub.lu.se:5d2077f0-1ddb-4387-bedd-5d50b87c515f" >
Tailored approaches...
Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia
-
- Baliakas, Panagiotis, 1977- (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
-
- Moysiadis, Theodoros (author)
- Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
-
- Hadzidimitriou, Anastasia (author)
- Uppsala universitet,Uppsala University,Center for Research and Technology Hellas,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
-
show more...
-
- Xochelli, Aliki (author)
- Uppsala universitet,Uppsala University,Center for Research and Technology Hellas,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
-
- Jeromin, Sabine (author)
- Munich Leukemia Laboratory (MLL),MLL Munich Leukemia Lab, Munich, Germany
-
- Agathangelidis, Andreas (author)
- Karolinska Institutet,Center for Research and Technology Hellas
-
- Mattsson, Mattias (author)
- Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
-
- Sutton, Lesley Ann (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
-
- Minga, Eva (author)
- Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
-
- Scarfò, Lydia (author)
- Vita-Salute San Raffaele University,San Raffaele Scientific Institute,IRCCS Ist Sci San Raffaele, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
-
- Rossi, Davide (author)
- Oncology Institute of Southern Switzerland,Oncol Inst Southern Switzerland, Bellinzona, Switzerland
-
- Davis, Zadie (author)
- Royal Bournemouth Hospital,Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
-
- Villamor, Neus (author)
- Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain
-
- Parker, Helen (author)
- University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
-
- Kotaskova, Jana (author)
- Masaryk University,University Hospital Brno,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
-
- Stalika, Evangelia (author)
- George Papanicolaou General Hospital,Center for Research and Technology Hellas,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece;G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
-
- Plevova, Karla (author)
- University Hospital Brno,Masaryk University,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
-
- Mansouri, Larry (author)
- Karolinska Institutet,Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
-
- Cortese, Diego (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
-
- Navarro, Alba (author)
- Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain
-
- Delgado, Julio (author)
- Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain
-
- Larrayoz, Marta (author)
- University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
-
- Young, Emma (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
-
- Anagnostopoulos, Achilles (author)
- George Papanicolaou General Hospital,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
-
- Smedby, Karin E. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden
-
- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Lund Univ & Hosp, Lund Stem Cell Ctr, Dept Hematol, Lund, Sweden
-
- Sheehy, Oonagh (author)
- Belfast City Hospital,Belfast City Hosp, Dept Hematooncol, Belfast, Antrim, North Ireland
-
- Catherwood, Mark (author)
- Belfast City Hospital,Belfast City Hosp, Dept Hematooncol, Belfast, Antrim, North Ireland
-
- Strefford, Jonathan C. (author)
- University of Southampton,Univ Southampton, Canc Res UK Ctr, Acad Unit Canc Sci, Canc Genon, Southampton, Hants, England;Univ Southampton, Fac Med, Expt Canc Med Ctr, Southampton, Hants, England
-
- Stavroyianni, Niki (author)
- George Papanicolaou General Hospital,G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece
-
- Belessi, Chrysoula (author)
- Nikea General Hospital, Piraeus,Nikea Gen Hosp, Hematol Dept, Piraeus, Greece
-
- Pospisilova, Sarka (author)
- Masaryk University,University Hospital Brno,Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic;Univ Hosp Brno, Brno, Czech Republic
-
- Oscier, David (author)
- Royal Bournemouth Hospital,Royal Bournemouth Hosp, Dept Haematol, Bournemouth, Dorset, England
-
- Gaidano, Gianluca (author)
- University of Eastern Piedmont,Amedeo Avogadro Univ Eastern Piedmont, Dept Translat Med, Div Hematol, Novara, Italy
-
- Campo, Elias (author)
- University of Barcelona,Hospital Clínic of Barcelona,Hosp Clin Barcelona, Hemopathol Unit, Barcelona, Spain;Univ Barcelona, Dept Pathol, Barcelona, Spain
-
- Haferlach, Claudia (author)
- Munich Leukemia Laboratory (MLL),MLL Munich Leukemia Lab, Munich, Germany
-
- Ghia, Paolo (author)
- Vita-Salute San Raffaele University,San Raffaele Scientific Institute,IRCCS Ist Sci San Raffaele, Div Expt Oncol, Milan, Italy;Univ Vita Salute San Raffaele, Milan, Italy
-
- Rosenquist, Richard (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
-
- Stamatopoulos, Kostas (author)
- Uppsala University,Center for Research and Technology Hellas,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden
-
show less...
-
(creator_code:org_t)
-
- 2018-09-27
- 2019
- English 10 s.
-
In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 104:2, s. 360-369
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.3...
-
https://doi.org/10.3...
-
https://uu.diva-port... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicators may differ between these two categories. Within Binet A M-CLL patients, besides TP53 abnormalities, trisomy 12 and stereotyped subset #2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years after diagnosis of 40% and 55%, respectively; the remaining cases exhibited 5-year and 10-year treatment probability of 12% and 25%, respectively. Within Binet A U-CLL patients, besides TP53 abnormalities, del(11q) and/or SF3B1 mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respectively); in the remaining cases, males had a significantly worse prognosis than females. In conclusion, the relative weight of indicators that can accurately risk stratify early-stage CLL patients differs depending on the somatic hypermutation status of the immunoglobulin heavy variable genes of each patient. This finding highlights the fact that compartmentalized approaches based on immunogenetic features are necessary to refine and tailor prognostication in CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Baliakas, Panagi ...
-
Moysiadis, Theod ...
-
Hadzidimitriou, ...
-
Xochelli, Aliki
-
Jeromin, Sabine
-
Agathangelidis, ...
-
show more...
-
Mattsson, Mattia ...
-
Sutton, Lesley A ...
-
Minga, Eva
-
Scarfò, Lydia
-
Rossi, Davide
-
Davis, Zadie
-
Villamor, Neus
-
Parker, Helen
-
Kotaskova, Jana
-
Stalika, Evangel ...
-
Plevova, Karla
-
Mansouri, Larry
-
Cortese, Diego
-
Navarro, Alba
-
Delgado, Julio
-
Larrayoz, Marta
-
Young, Emma
-
Anagnostopoulos, ...
-
Smedby, Karin E.
-
Juliusson, Gunna ...
-
Sheehy, Oonagh
-
Catherwood, Mark
-
Strefford, Jonat ...
-
Stavroyianni, Ni ...
-
Belessi, Chrysou ...
-
Pospisilova, Sar ...
-
Oscier, David
-
Gaidano, Gianluc ...
-
Campo, Elias
-
Haferlach, Claud ...
-
Ghia, Paolo
-
Rosenquist, Rich ...
-
Stamatopoulos, K ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Haematologica
- By the university
-
Lund University
-
Uppsala University
-
Karolinska Institutet