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Thrombolysis in the...
Thrombolysis in the developing world: is there a role for streptokinase?
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Butcher, Ken (author)
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Shuaib, Ashfaq (author)
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Saver, Jeffrey (author)
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Donnan, Geoffrey (author)
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Davis, Stephen M. (author)
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- Norrving, Bo (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Wong, K. S. Lawrence (author)
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Abd-Allah, Foad (author)
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Bhatia, Rohit (author)
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Khan, Adnan (author)
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(creator_code:org_t)
- 2013-01-21
- 2013
- English.
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In: International Journal of Stroke. - : SAGE Publications. - 1747-4949 .- 1747-4930. ; 8:7, s. 560-565
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
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- Intravenous thrombolysis with tissue plasminogen activator is the only proven acute therapy for ischemic stroke. This therapy has not been translated into clinical practice in the developing world primarily due to economic constraints. Streptokinase, a lower cost alternative thrombolytic agent, is widely available in developing countries where it is utilized to treat patients with acute coronary syndromes. Although this drug has previously been found to be ineffective in ischemic stroke, the lack of benefit may have been related to a number of factors related to trial design rather than the drug itself. Specific features of prior trial designs that may have adversely affected outcomes include a prolonged treatment window, inclusion of patients with established infarction on computed tomography scan, failure to treat excessive arterial pressures, a fixed dose of streptokinase, and concomitant use of antithrombotic medications. Given the lack of therapeutic alternatives in developing countries, a new trial of streptokinase in acute stroke, utilizing stricter inclusion criteria similar to those in more recent thrombolytic studies, appears warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- acute stroke therapy
- clinical trial
- cost factors
- developing
- countries
- ischemic stroke
- thrombolysis
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- ref (subject category)
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- By the author/editor
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Butcher, Ken
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Shuaib, Ashfaq
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Saver, Jeffrey
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Donnan, Geoffrey
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Davis, Stephen M ...
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Norrving, Bo
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show more...
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Wong, K. S. Lawr ...
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Abd-Allah, Foad
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Bhatia, Rohit
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Khan, Adnan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Lund University