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Lipid-associated ma...
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications
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- Dib, Lea (author)
- University of Oxford
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- Koneva, Lada A. (author)
- University of Oxford
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- Edsfeldt, Andreas (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Zurke, Yasemin Xiomara (author)
- University of Oxford
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- Sun, Jiangming (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups
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- Nitulescu, Mihaela (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups
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- Attar, Moustafa (author)
- University of Oxford
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- Lutgens, Esther (author)
- Mayo Clinic Minnesota
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- Schmidt, Steffen (author)
- Roche Innovation Center Copenhagen
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- Lindholm, Marie W. (author)
- Roche Innovation Center Copenhagen
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- Choudhury, Robin P. (author)
- University of Oxford
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- Cassimjee, Ismail (author)
- University of Oxford
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- Lee, Regent (author)
- University of Oxford
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- Handa, Ashok (author)
- University of Oxford
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- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Sansom, Stephen N. (author)
- University of Oxford
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- Monaco, Claudia (author)
- University of Oxford
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nature Cardiovascular Research. - 2731-0590. ; 2:7, s. 656-672
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Abstract
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- The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far from single-cell atlases suggests a dichotomy between lipid-associated and inflammatory macrophage states. Here, we present an inclusive reference atlas of human intraplaque immune cell communities. Combining single-cell RNA sequencing (scRNA-seq) of human surgical carotid endarterectomies in a discovery cohort with bulk RNA-seq and immunohistochemistry in a validation cohort (the Carotid Plaque Imaging Project), we reveal the existence of PLIN2hi/TREM1hi macrophages as a Toll-like receptor (TLR)-dependent inflammatory lipid-associated macrophage state linked to cerebrovascular events. Our study shifts the current paradigm of lipid-driven inflammation by providing biological evidence for a pathogenic macrophage transition to an inflammatory lipid-associated phenotype and for its targeting as a new treatment strategy for cardiovascular disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Dib, Lea
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Koneva, Lada A.
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Edsfeldt, Andrea ...
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Zurke, Yasemin X ...
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Sun, Jiangming
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Nitulescu, Mihae ...
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show more...
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Attar, Moustafa
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Lutgens, Esther
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Schmidt, Steffen
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Lindholm, Marie ...
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Choudhury, Robin ...
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Cassimjee, Ismai ...
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Lee, Regent
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Handa, Ashok
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Goncalves, Isabe ...
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Sansom, Stephen ...
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Monaco, Claudia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Cardiovas ...
- By the university
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Lund University