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Bone morphogenetic ...
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-03-21
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Springer Science and Business Media LLC,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:5ea4548b-0431-4702-9353-38f4ec17b6ed
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https://lup.lub.lu.se/record/4379870URI
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https://doi.org/10.1038/bcj.2014.16DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8-809) compared with healthy controls (median 110 pg/ml, range 8-359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wader, K F
(author)
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Misund, K
(author)
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Våtsveen, T K
(author)
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Rø, T B
(author)
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Mylin, A K
(author)
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Turesson, IngemarLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)medf-itu
(author)
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Størdal, B F
(author)
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Moen, S H
(author)
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Standal, T
(author)
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Waage, A
(author)
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Sundan, A
(author)
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Holien, T
(author)
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Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
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In:Blood Cancer Journal: Springer Science and Business Media LLC4:Mar 21, s. 196-1962044-5385
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Olsen, O E
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Wader, K F
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Misund, K
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Våtsveen, T K
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Rø, T B
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Mylin, A K
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Turesson, Ingema ...
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Størdal, B F
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Moen, S H
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Standal, T
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Waage, A
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Sundan, A
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Holien, T
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Blood Cancer Jou ...
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Lund University