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- Olsen, O E (author)
Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
- Article/chapterEnglish2014
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- 2014-03-21
- Springer Science and Business Media LLC,2014
- electronicrdacarrier
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- LIBRIS-ID:oai:lup.lub.lu.se:5ea4548b-0431-4702-9353-38f4ec17b6ed
- https://lup.lub.lu.se/record/4379870URI
- https://doi.org/10.1038/bcj.2014.16DOI
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- Language:English
- Summary in:English
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- Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8-809) compared with healthy controls (median 110 pg/ml, range 8-359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma.
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- Wader, K F (author)
- Misund, K (author)
- Våtsveen, T K (author)
- Rø, T B (author)
- Mylin, A K (author)
- Turesson, IngemarLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)medf-itu (author)
- Størdal, B F (author)
- Moen, S H (author)
- Standal, T (author)
- Waage, A (author)
- Sundan, A (author)
- Holien, T (author)
- Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin (creator_code:org_t)
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- In:Blood Cancer Journal: Springer Science and Business Media LLC4:Mar 21, s. 196-1962044-5385
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