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Advanced Intercross...
Advanced Intercross Line Mapping Suggests That Ncf1 (Ean6) Regulates Severity in an Animal Model of Guillain-Barre Syndrome
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Huberle, Alexander (author)
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Beyeen, Amennai Daniel (author)
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- Ockinger, Johan (author)
- Karolinska Institutet
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Ayturan, Miriam (author)
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- Jagodic, Maja (author)
- Karolinska Institutet
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de Graaf, Katrien L. (author)
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Fissolo, Nicolas (author)
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Marta, Monica (author)
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Olofsson, Peter (author)
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- Hultqvist, Malin (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Holmdahl, Rikard (author)
- Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Olsson, Tomas (author)
- Karolinska Institutet
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Weissert, Robert (author)
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(creator_code:org_t)
- The American Association of Immunologists, 2009
- 2009
- English.
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In: Journal of Immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 182:7, s. 4432-4438
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http://dx.doi.org/10...
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http://www.jimmunol....
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Abstract
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- We here present the first genetic fine mapping of experimental autoimmune neuritis (EAN), the animal model of Guillain-Barre syndrome, in a rat advanced intercross line. We identified and refined a total of five quantitative trait loci on rat chromosomes 4, 10, and 12 (RNO4, RNO10, RNO12), showing linkage to splenic IFN-gamma secretion and disease severity. All quantitative trait loci were shared with other models of complex inflammatory diseases. The quantitative trait locus showing strongest linkage to clinical disease was Ean6 and spans 4.3 Mb on RNO12, harboring the neutrophil cytosolic factor 1 (Ncf1) among other genes. Polymorphisms in Ncf1, a member of the NADPH oxidase complex, have been associated with disease regulation in experimental arthritis and encephalomyelitis. We therefore tested the Ncf1 pathway by treating rats with a NADPH oxidase complex activator and ameliorated EAN compared the oil-treated control group. By proving the therapeutic effect of stimulating the NADPH oxidase complex, our data strongly suggest the first identification of a gene regulating peripheral nervous system inflammation. Taken together with previous reports, our findings suggest a general role of Ncf1 and oxidative burst in pathogenesis of experimental autoimmune animal models. The Journal of Immunology, 2009, 182: 4432-4438.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Huberle, Alexand ...
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Beyeen, Amennai ...
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Ockinger, Johan
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Ayturan, Miriam
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Jagodic, Maja
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de Graaf, Katrie ...
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show more...
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Fissolo, Nicolas
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Marta, Monica
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Olofsson, Peter
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Hultqvist, Malin
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Holmdahl, Rikard
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Olsson, Tomas
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Weissert, Robert
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Journal of Immun ...
- By the university
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Lund University
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Karolinska Institutet