Brain temperature in volunteers subjected to intranasal cooling

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Covaciu, LucianUppsala universitet,Anestesiologi och intensivvård (author)

Brain temperature in volunteers subjected to intranasal cooling

Article/chapterEnglish2011

Publisher, publication year, extent ...

2011-06-07
Springer Science and Business Media LLC,2011

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LIBRIS-ID:oai:lup.lub.lu.se:5f61f407-9266-4528-bb00-37581a2f3c99
https://lup.lub.lu.se/record/2091583URI
https://doi.org/10.1007/s00134-011-2264-7DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156896URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

Notes

Intranasal cooling can be used to initiate therapeutic hypothermia. However, direct measurement of brain temperature is difficult and the intra-cerebral distribution of temperature changes with cooling is unknown. The purpose of this study was to measure the brain temperature of human volunteers subjected to intranasal cooling using non-invasive magnetic resonance (MR) methods. Intranasal balloons catheters circulated with saline at 20A degrees C were applied for 60 min in ten awake volunteers. No sedation was used. Brain temperature changes were measured and mapped using MR spectroscopic imaging (MRSI) and phase-mapping techniques. Heart rate and blood pressure were monitored throughout the experiment. Rectal temperature was measured before and after the cooling. Mini Mental State Examination (MMSE) test and nasal inspection were done before and after the cooling. Questionnaires about the subjects' personal experience were completed after the experiment. Brain temperature decrease measured by MRSI was -1.7 +/- A 0.8A degrees C and by phase-mapping -1.8 +/- A 0.9A degrees C (n = 9) at the end of cooling. Spatial distribution of temperature changes was relatively uniform. Rectal temperature decreased by -0.5 +/- A 0.3A degrees C (n = 5). The physiological parameters were stable and no shivering was reported. The volunteers remained alert during cooling and no cognitive dysfunctions were apparent in the MMSE test. Postcooling nasal examination detected increased nasal secretion in nine of the ten volunteers. Volunteers' acceptance of the method was good. Both MR techniques revealed brain temperature reductions after 60 min of intranasal cooling with balloons circulated with saline at 20A degrees C in awake, unsedated volunteers.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Therapeutic hypothermia
Brain temperature
Magnetic resonance
spectroscopy
Selective brain cooling
Trigeminal reflex
Anaesthetics and intensive care
Radiology

Added entries (persons, corporate bodies, meetings, titles ...)

Weis, JanUppsala universitet,Enheten för radiologi(Swepub:uu)janweis (author)
Bengtsson, CarolineUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)carbe980 (author)
Allers, M. (author)
Lunderquist, AndersLund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-alt (author)
Ahlström, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hakanahl (author)
Rubertsson, StenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)stenrube (author)
Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

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In:Intensive Care Medicine: Springer Science and Business Media LLC37:8, s. 1277-12840342-46421432-1238

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