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A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.
- Veitonmäki, Niina (author)
-
- Hansson, Markus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
- Zhan, Fenghuang (author)
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- Sundberg, Annika (author)
- Ljungars, Anne (author)
- Li, Zhan-Chun (author)
- Martinsson-Niskanen, Titti (author)
- Zeng, Ming (author)
- Yang, Ye (author)
- Danielsson, Lena (author)
- Lundqvist, Andrea (author)
- Tricot, Guido (author)
- Frendéus, Björn (author)
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- (creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
- In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 23:4, s. 502-515
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering "function-first" approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Zhan, Fenghuang
- Sundberg, Annika
- Löfstedt, Tobias
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- Li, Zhan-Chun
- Martinsson-Niska ...
- Zeng, Ming
- Yang, Ye
- Danielsson, Lena
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- Teige, Ingrid
- Tricot, Guido
- Frendéus, Björn
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- Cancer Cell
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- Lund University
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