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Neutrophil secretio...
Neutrophil secretion products pave the way for inflammatory monocytes
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- Soehnlein, Oliver (author)
- Karolinska Institutet
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Zernecke, Alma (author)
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- Eriksson, Einar E. (author)
- Karolinska Institutet
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Rothfuchs, Antonio Gigliotti (author)
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Pham, Christine T. (author)
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- Herwald, Heiko (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Bidzhekov, Kiril (author)
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Rottenberg, Martin E. (author)
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Weber, Christian (author)
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- Lindbom, Lennart (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Society of Hematology, 2008
- 2008
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 112:4, s. 1461-1471
- Related links:
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http://dx.doi.org/10... (free)
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The leukocyte response in inflammation is characterized by an initial recruitment of polymorphonuclear leukocytes (PMN) preceding a second wave of monocytes to the site of injury or infection. In the mouse, 2 populations of monocytes have been identified, Gr1-CCR2-CX3CR1(hi) resident monocytes and Gr1+CCR2+CX3CR1(lo) inflammatory monocytes. Here, intravital microscopy of the musculus cremasterand a subcutaneous air pouch model were used to investigate a possible link between PMN extravasation and the subsequent emigration of inflammatory monocytes in response to local stimulation with PAR In mice that were made neutropenic by injection of a PMN-depleting antibody, the extravasation of inflammatory monocytes, but not resident monocytes, was markedly reduced compared with mice with intact white blood cell count but was restored by local treatment with secretion of activated PMN. Components of the PMN secretion were found to and further examination revealed PMN-derived LL-37 and heparin-binding protein (HBP/CAP37/azurocidin) as primary mediators of the recruitment of inflammatory monocytes via activation of formyl-peptide receptors. These data show that LL-37 and HBP specifically stimulate mobilization of inflammatory monocytes. This cellular cross-talk functionally results in enhanced cytokine levels and increased bacterial clearance, thus boosting the early immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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- By the author/editor
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Soehnlein, Olive ...
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Zernecke, Alma
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Eriksson, Einar ...
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Rothfuchs, Anton ...
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Pham, Christine ...
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Herwald, Heiko
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show more...
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Bidzhekov, Kiril
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Rottenberg, Mart ...
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Weber, Christian
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Lindbom, Lennart
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University
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Karolinska Institutet