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  • Bhattacharya, RomitMassachusetts General Hospital,Massachusetts Institute of Technology,Harvard Medical School (author)

Clonal Hematopoiesis Is Associated with Higher Risk of Stroke

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022
  • 10 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:618e79be-362b-4489-88a2-3f34669920d3
  • https://lup.lub.lu.se/record/618e79be-362b-4489-88a2-3f34669920d3URI
  • https://doi.org/10.1161/STROKEAHA.121.037388DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke. Methods: We utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (DNMT3A, TET2, and ASXL1) with any stroke, ischemic stroke, and hemorrhagic stroke. Results: CHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03-1.27]; P=0.01) after adjustment for age, sex, and race. We observed associations with CHIP with risk of hemorrhagic stroke (hazard ratio, 1.24 [95% CI, 1.01-1.51]; P=0.04) and with small vessel ischemic stroke subtypes. In gene-specific association results, TET2 showed the strongest association with total stroke and ischemic stroke, whereas DMNT3A and TET2 were each associated with increased risk of hemorrhagic stroke. Conclusions: CHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Zekavat, Seyedeh M.Yale University School of Medicine,Massachusetts Institute of Technology,Massachusetts General Hospital (author)
  • Haessler, JeffreyFred Hutchinson Cancer Research Center (author)
  • Fornage, MyriamUniversity of Texas (author)
  • Raffield, LauraUniversity of North Carolina (author)
  • Uddin, Md MesbahMassachusetts Institute of Technology,Massachusetts General Hospital (author)
  • Bick, Alexander G.Vanderbilt University Medical Center (author)
  • Niroula, AbhishekLund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Dana-Farber Cancer Institute,Massachusetts Institute of Technology(Swepub:lu)med-anu (author)
  • Yu, BingUniversity of Texas (author)
  • Gibson, ChristopherDana-Farber Cancer Institute (author)
  • Griffin, GabrielBroad Institute,Brigham and Women's Hospital / Harvard Medical School (author)
  • Morrison, Alanna C.University of Texas,Massachusetts General Hospital (author)
  • Psaty, Bruce M.Washington University School of Medicine (author)
  • Longstreth, William T.University of Washington (author)
  • Bis, Joshua C.Washington University School of Medicine (author)
  • Rich, Stephen S.University of Virginia School of Medicine (author)
  • Rotter, Jerome I.University of California, Los Angeles (author)
  • Tracy, Russell P.University of Vermont (author)
  • Correa, AdolfoUniversity of Mississippi Medical Center (author)
  • Seshadri, SudhaUniversity of Texas at San Antonio,Boston University (author)
  • Johnson, AndrewNational Heart Lung and Blood Institute,Boston University (author)
  • Collins, Jason M.University of North Carolina (author)
  • Hayden, Kathleen M.Wake Forest University (author)
  • Madsen, Tracy E.Brown University (author)
  • Ballantyne, Christie M.Baylor College of Medicine (author)
  • Jaiswal, SiddharthaUniversity of California, San Francisco (author)
  • Ebert, Benjamin L.Howard Hughes Medical Institute,Dana-Farber Cancer Institute (author)
  • Kooperberg, CharlesFred Hutchinson Cancer Research Center (author)
  • Manson, Joann E.Harvard Medical School (author)
  • Whitsel, Eric A.University of North Carolina (author)
  • Natarajan, PradeepHarvard Medical School,Massachusetts Institute of Technology,Massachusetts General Hospital (author)
  • Reiner, Alexander P.University of Washington (author)
  • Massachusetts General HospitalMassachusetts Institute of Technology (creator_code:org_t)

Related titles

  • In:Stroke29:2, s. 788-7970039-2499

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