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Challenges and cons...
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Ekberg, HenrikLund University,Lunds universitet,Enheten för forskning kring njurfunktion och njursjukdom,Kirurgi,Forskargrupper vid Lunds universitet,Renal Research Unit,Surgery,Lund University Research Groups
(author)
Challenges and considerations in diagnosing the kidney disease in deteriorating graft function.
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-06-28
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Frontiers Media SA,2012
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LIBRIS-ID:oai:lup.lub.lu.se:61aa7439-8dc3-4e4e-b10f-764116a7aa1e
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https://lup.lub.lu.se/record/2858916URI
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https://doi.org/10.1111/j.1432-2277.2012.01516.xDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Despite significant reductions in acute-rejection rates with the introduction of calcineurin inhibitor (CNI)-based immunosuppressive therapy, improvements in long-term graft survival in renal transplantation have been mixed. Improving long-term graft survival continues to present a major challenge in the management of kidney-transplant patients. CNIs are a key component of immunosuppressive therapy, and chronic CNI toxicity has been widely thought to be a major factor in late graft failure. However, recent studies examining the causes of late graft failure in detail have challenged this view, highlighting the importance of antibody-mediated rejection and other factors. In addition, the diagnosis of CNI nephrotoxicity represents a challenge to clinicians, with the potential for over-diagnosis and an inappropriate reduction in immunosuppressive therapy. When graft function is deteriorating, accurately determining the cause of the kidney disease is essential for effective long-term management of the patient. Diagnosis requires a thorough clinical investigation, and in the majority of cases a specific cause can be identified.
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Johansson, Martin E
(author)
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Enheten för forskning kring njurfunktion och njursjukdomKirurgi
(creator_code:org_t)
Related titles
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In:Transplant international : official journal of the European Society for Organ Transplantation: Frontiers Media SA25:11, s. 1119-11281432-2277
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In:Transplant International: Frontiers Media SA25:11, s. 1119-11280934-0874
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