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Search: onr:"swepub:oai:lup.lub.lu.se:61be4622-e5e2-4dc9-8bd4-8c396449a2e8" > The impact of amylo...

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  • Rhodes, EmmaSan Francisco Veterans Administration Medical Center (author)

The impact of amyloid burden and APOE on rates of cognitive impairment in late life depression

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:61be4622-e5e2-4dc9-8bd4-8c396449a2e8
  • https://lup.lub.lu.se/record/61be4622-e5e2-4dc9-8bd4-8c396449a2e8URI
  • https://doi.org/10.3233/JAD-201089DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Cognitive impairment (CI) is a key feature of late life depression (LLD), but the contribution of underlying neurodegenerative pathology remains unclear. Objective: To evaluate cognitive dysfunction in LLD relative to a sample of nondepressed (ND) older adults with matched levels of memory impairment and amyloid-β (Aβ) burden. Methods: Participants included 120 LLD and 240 ND older adults matched on age, education, sex, Mini-Mental State Exam, mild cognitive impairment diagnosis, and PET Aβ burden. Results: LLD showed higher rates of impairment relative to ND with 54.6% of the LLD sample demonstrating impairment in at least one cognitive domain compared to 42.9% of controls (H = 7.13, p = 0.008). LLD had poorer performance and higher rates of impairment on Rey Auditory Verbal Learning Test learning and memory compared to controls. In the overall sample, Aβ positivity was associated with worse performance on Logical Memory I (p = 0.044), Logical Memory II (p = 0.011), and Trail Making Test -B (p = 0.032), and APOE ϵ4 genotype was associated with worse performance on Logical Memory I (p =0.022); these relationships did not differ between LLD and ND. Conclusion: LLD showed higher rates of CI driven by focal deficits in verbal learning and memory. Alzheimer's disease (AD) biomarkers were associated with worse performance on timed set-shifting and story learning and memory, and these relationships were not impacted by depression status. These findings suggest that AD may account for a portion of previously reported multi-domain CI in LLD and highlight the potential for AD to confound studies of cognition in LLD.

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  • Insel, Philip S.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,University of California, San Francisco(Swepub:lu)med-ppi (author)
  • Butters, Meryl A.University of Pittsburgh (author)
  • Morin, RuthSan Francisco Veterans Administration Medical Center (author)
  • Bickford, DavidUniversity of California, San Francisco (author)
  • Tosun, DuyguSan Francisco Veterans Administration Medical Center,University of California, San Francisco (author)
  • Gessert, DevonUniversity of Southern California (author)
  • Rosen, Howie J.University of California, San Francisco (author)
  • Aisen, PaulUniversity of Southern California (author)
  • Raman, RemaUniversity of Southern California (author)
  • Landau, SusanUniversity of California, Berkeley (author)
  • Saykin, AndrewIndiana University (author)
  • Toga, ArthurUniversity of Southern California (author)
  • Jack, Clifford R.Mayo Clinic Minnesota (author)
  • Weiner, Michael W.San Francisco Veterans Administration Medical Center,University of California, San Francisco (author)
  • Nelson, CraigUniversity of California, San Francisco (author)
  • MacKin, R. ScottUniversity of Pittsburgh,University of California, San Francisco (author)
  • San Francisco Veterans Administration Medical CenterKlinisk minnesforskning (creator_code:org_t)
  • Alzheimer's Disease Neuroimaging Initiative
  • ADNI Depression Project

Related titles

  • In:Journal of Alzheimer's Disease80:3, s. 991-10021387-2877

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