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Hospital admission for neurologic disorders among 5-year survivors of noncentral nervous system tumors in childhood : A cohort study within the Adult Life after Childhood Cancer in Scandinavia study
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- Kenborg, Line (author)
- Danish Cancer Society
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- Linnet, Karen M. (author)
- Aarhus University Hospital
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- de Fine Licht, Sofie (author)
- Danish Cancer Society
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- Bautz, Andrea (author)
- Danish Cancer Society
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- Holmqvist, Anna S. (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital
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- Tryggvadottir, Laufey (author)
- University of Iceland,Icelandic Cancer Registry
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- Madanat-Harjuoja, Laura M. (author)
- Finnish Cancer Registry
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- Stovall, Marilyn (author)
- University of Texas
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- Heilmann, Carsten (author)
- Copenhagen University Hospital
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- Albieri, Vanna (author)
- Danish Cancer Society
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- Hasle, Henrik (author)
- Aarhus University Hospital
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- Winther, Jeanette F. (author)
- Aarhus University Hospital,Danish Cancer Society
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(creator_code:org_t)
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- 2019-04-29
- 2020
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 146:3, s. 819-828
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Abstract
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- Large, comprehensive studies of the risk for neurologic disorders among long-term survivors of noncentral nervous system (CNS) childhood cancers are lacking. Thus, the aim of our study was to assess the lifetime risk of Nordic non-CNS childhood cancer survivors for neurologic disorders. We identified 15,967 5-year survivors of non-CNS childhood cancer diagnosed in Denmark, Iceland, Finland and Sweden in 1943–2008, and 151,118 matched population comparison subjects. In-patient discharge diagnoses of neurologic disorders were used to calculate relative risks (RRs) and absolute excess risks (AERs). A neurologic disorder was diagnosed in 755 of the survivors while 370 were expected, yielding a RR of 2.0 (95% confidence interval (CI) 1.9–2.2). The highest risks were found among survivors of neuroblastoma (4.1; 95% CI 3.2–5.3) and leukemia (2.8; 95% CI 2.4–3.2). The AER decreased from 331 (278–383) excess neurologic disorders per 100,000 person-years 5–9 years after diagnosis to 82 (46–118) ≥ 20 years after diagnosis. Epilepsy was the most common diagnosis (n = 229, 1.4% of all survivors), and significantly increased risks were seen among survivors of eight out of 12 types of childhood cancer. Survivors of neuroblastoma had remarkably high risks (RR ≥ 10) for hospitalization for paralytic syndromes and hydrocephalus, while survivors of leukemia had additional high risks for dementia and encephalopathy. In conclusion, survivors of non-CNS childhood cancer are at high risk for neurologic disorders, especially within the first decade after diagnosis. Therefore, intensive follow-up to identify those who require close management is needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- childhood cancer
- cohort study
- late effects
- neurologic disorders
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kenborg, Line
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Linnet, Karen M.
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de Fine Licht, S ...
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Bautz, Andrea
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Holmqvist, Anna ...
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Tryggvadottir, L ...
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show more...
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Madanat-Harjuoja ...
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Stovall, Marilyn
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Heilmann, Carste ...
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Albieri, Vanna
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Hasle, Henrik
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Winther, Jeanett ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Lund University