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Monitoring CAR-T-Ce...
Monitoring CAR-T-Cell Therapies Using the Nordic Healthcare Databases
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- Callréus, Torbjörn (author)
- University of Copenhagen
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- El-Galaly, Tarec Christoffer (author)
- Aalborg University Hospital
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- Jerkeman, Mats (author)
- Lund University,Lunds universitet,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,Lymphoma - Clinical Research,Lund University Research Groups
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- de Nully Brown, Peter (author)
- Copenhagen University Hospital
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- Andersen, Morten (author)
- University of Copenhagen
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(creator_code:org_t)
- 2019-03-13
- 2019
- English 6 s.
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In: Pharmaceutical Medicine. - : Springer Science and Business Media LLC. - 1178-2595 .- 1179-1993. ; 33:2, s. 83-88
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Abstract
Subject headings
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- Following intense research efforts, modulation of the immune system has finally proved to be a viable approach for treating malignant disease. Recently, chimeric antigen receptor redirected T cells have achieved promising outcomes in patients with B-cell malignancies and they are currently also being investigated in other haematological malignancies, solid tumours and viral infections. Compared with traditional biopharmaceuticals, the properties of genetically modified chimeric antigen receptor redirected T-cell therapies differ in many aspects, thereby posing challenges in terms of post-authorisation data collection and data analysis. We believe that the network of population-based Nordic healthcare databases has some characteristics that can help provide important data on these new types of advanced products. In particular, the possibility of very long follow-up periods with a limited loss to follow-up is an important strength. Given the limited source population and slow access to data, a Nordic chimeric antigen receptor redirected T-cell monitoring project should be seen as complementary to other surveillance initiatives.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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