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Designing stem-cell...
Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease
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- Barker, Roger A. (author)
- University of Cambridge
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- Farrell, Krista (author)
- University of Cambridge
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- Guzman, Natalie Valle (author)
- University of Cambridge
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- He, Xiaoling (author)
- University of Cambridge
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- Lazic, Stanley E. (author)
- Cardiff University
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- Moore, Sarah (author)
- University of Cambridge
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- Morris, Robert (author)
- Addenbrooke's Hospital
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- Tyers, Pamela (author)
- University of Cambridge
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- Wijeyekoon, Ruwani (author)
- University of Cambridge
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- Daft, Danielle (author)
- University of Cambridge
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- Hewitt, Sam (author)
- University of Cambridge
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- Dayal, Viswas (author)
- University College London,National Hospital for Neurology and Neurosurgery
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- Foltynie, Thomas (author)
- National Hospital for Neurology and Neurosurgery,University College London
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- Kefalopoulou, Zinovia (author)
- University College London,National Hospital for Neurology and Neurosurgery
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- Mahlknecht, Philipp (author)
- National Hospital for Neurology and Neurosurgery,University College London
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- Lao-Kaim, Nick P. (author)
- Imperial College London
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- Piccini, Paola (author)
- Imperial College London
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- Bjartmarz, Hjalmar (author)
- Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Lund University Research Groups
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- Björklund, Anders (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Nelander-Wahlestedt, Jenny (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Parmar, Malin (author)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Paul, Gesine (author)
- Skåne University Hospital
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- Widner, Hakan (author)
- Skåne University Hospital
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- Church, Alistair (author)
- Cardiff University
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- Dunnett, Stephen (author)
- Cardiff University
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- Peall, Kathryn (author)
- Cardiff University
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- Rosser, Anne (author)
- Cardiff University
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- Gurruchaga, Jean Marc (author)
- Henri Mondor Hospital
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- Palfi, Stéphane (author)
- Henri Mondor Hospital
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- Piroth, Tobias (author)
- Albert-Ludwigs University Freiburg
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- Winkler, Christian (author)
- Albert-Ludwigs University Freiburg
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(creator_code:org_t)
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- 2019-07-01
- 2019
- English 9 s.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 25, s. 1045-1053
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Abstract
Subject headings
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- Clinical studies of Parkinson’s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia. This led to a re-appraisal of the best way to do such trials, which resulted in a new European-Union-funded allograft trial with fetal dopamine cells across several centers in Europe. This new trial, TRANSEURO (NCT01898390), is an open-label study in which some individuals in a large observational cohort of patients with mild PD who were undergoing identical assessments were randomly selected to receive transplants of hfVM. The TRANSEURO trial is currently ongoing as researchers have completed both recruitment into a large multicenter observational study of younger onset early-stage PD and transplantation of hfVM in 11 patients. While completion of TRANSEURO is not expected until 2021, we feel that sharing the rationale for the design of TRANSEURO, along with the lessons we have learned along the way, can help inform researchers and facilitate planning of transplants of dopamine-producing cells derived from human pluripotent stem cells for future clinical trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Barker, Roger A.
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Farrell, Krista
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Guzman, Natalie ...
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He, Xiaoling
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Lazic, Stanley E ...
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Moore, Sarah
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show more...
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Morris, Robert
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Tyers, Pamela
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Wijeyekoon, Ruwa ...
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Daft, Danielle
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Hewitt, Sam
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Dayal, Viswas
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Foltynie, Thomas
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Kefalopoulou, Zi ...
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Mahlknecht, Phil ...
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Lao-Kaim, Nick P ...
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Piccini, Paola
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Bjartmarz, Hjalm ...
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Björklund, Ander ...
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Lindvall, Olle
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Nelander-Wahlest ...
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Parmar, Malin
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Paul, Gesine
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Widner, Hakan
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Church, Alistair
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Dunnett, Stephen
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Peall, Kathryn
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Rosser, Anne
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Gurruchaga, Jean ...
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Palfi, Stéphane
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Piroth, Tobias
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Winkler, Christi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Nature Medicine
- By the university
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Lund University