Impact of acquisition time and penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm on a Si-photomultiplier-based PET-CT system for 18F-FDG

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Impact of acquisition time and penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm on a Si-photomultiplier-based PET-CT system for 18F-FDG

Trägårdh, Elin (author): Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Nuclear medicine, Malmö,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital

Minarik, David (author): Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital

Almquist, Helén (author): Skåne University Hospital

Bitzén, Ulrika (author): Skåne University Hospital

Garpered, Sabine (author): Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital

Hvittfelt, Erland (author): Skåne University Hospital

Olsson, Berit (author): Skåne University Hospital

Oddstig, Jenny (author): Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital

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2019-07-24
2019
English.
In: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 9:1

Related links:: http://dx.doi.org/10... (free); show more...; https://ejnmmires.sp...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Block-sequential regularized expectation maximization (BSREM), commercially Q. Clear (GE Healthcare, Milwaukee, WI, USA), is a reconstruction algorithm that allows for a fully convergent iterative reconstruction leading to higher image contrast compared to conventional reconstruction algorithms, while also limiting noise. The noise penalization factor β controls the trade-off between noise level and resolution and can be adjusted by the user. The aim was to evaluate the influence of different β values for different activity time products (ATs = administered activity × acquisition time) in whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) regarding quantitative data, interpretation, and quality assessment of the images. Twenty-five patients with known or suspected malignancies, referred for clinical 18F-FDG PET-CT examinations acquired on a silicon photomultiplier PET-CT scanner, were included. The data were reconstructed using BSREM with β values of 100–700 and ATs of 4–16 MBq/kg × min/bed (acquisition times of 1, 1.5, 2, 3, and 4 min/bed). Noise level, lesion SUVmax, and lesion SUVpeak were calculated. Image quality and lesion detectability were assessed by four nuclear medicine physicians for acquisition times of 1.0 and 1.5 min/bed position. Results: The noise level decreased with increasing β values and ATs. Lesion SUVmax varied considerably between different β values and ATs, whereas SUVpeak was more stable. For an AT of 6 (in our case 1.5 min/bed), the best image quality was obtained with a β of 600 and the best lesion detectability with a β of 500. AT of 4 generated poor-quality images and false positive uptakes due to noise. Conclusions: For oncologic whole-body 18F-FDG examinations on a SiPM-based PET-CT, we propose using an AT of 6 (i.e., 4 MBq/kg and 1.5 min/bed) reconstructed with BSREM using a β value of 500–600 in order to ensure image quality and lesion detection rate as well as a high patient throughput. We do not recommend using AT < 6 since the risk of false positive uptakes due to noise increases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Keyword

Block-sequential regularized expectation maximization
FDG
Image reconstruction
PET-CT
Q. Clear

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By the author/editor: Trägårdh, Elin; Minarik, David; Almquist, Helén; Bitzén, Ulrika; Garpered, Sabine; Hvittfelt, Erlan ...; show more...; Olsson, Berit; Oddstig, Jenny; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

Articles in the publication: EJNMMI Research

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