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Estimating heritabi...
Estimating heritability of height without zygosity information for twins under five years in low- and middle-income countries : An application of normal finite mixture distribution models
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- Karlsson, Omar (author)
- Lund University,Lunds universitet,Ekonomisk-historiska institutionen,Ekonomihögskolan,Department of Economic History,Lund University School of Economics and Management, LUSEM,Harvard University
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- Domingue, Benjamin W. (author)
- Stanford University
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- Kim, Rockli (author)
- Korea University,Harvard Center for Population and Development Studies
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- Subramanian, S. V. (author)
- Harvard University,Harvard Center for Population and Development Studies
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: SSM - Population Health. - : Elsevier BV. - 2352-8273. ; 17
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Twin studies are widely used to estimate heritability of traits and typically rely on knowing the zygosity of twin pairs in order to determine variation attributable to genetics. Most twin studies are conducted in high resource settings. Large scale household survey data, such as the Demographic and Health Surveys, collect various biomarkers for children under five years old in low- and middle-income countries. These data include twins but no information on zygosity. We applied mixture models to obtain heritability estimates without knowing zygosity of twins, using 249 Demographic and Health Surveys from 79 low- and middle-income countries (14,524 twin pairs). We focused on height of children, adjusted for age and sex, but also provided estimates for other biomarkers available in the data. We estimated that the heritability of height in our sample was 46%.
Subject headings
- SAMHÄLLSVETENSKAP -- Ekonomi och näringsliv -- Ekonomisk historia (hsv//swe)
- SOCIAL SCIENCES -- Economics and Business -- Economic History (hsv//eng)
Keyword
- Height
- Heritability
- Low- and middle-income countries
- Twin studies
- Unknown zygosity
Publication and Content Type
- art (subject category)
- ref (subject category)
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