Search: onr:"swepub:oai:lup.lub.lu.se:62ecbdef-36c7-448e-b8ab-809c41705eee" >
Locus Coeruleus Deg...
-
Matti, NathalieLund University
(author)
Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:62ecbdef-36c7-448e-b8ab-809c41705eee
-
https://lup.lub.lu.se/record/62ecbdef-36c7-448e-b8ab-809c41705eeeURI
-
https://doi.org/10.3233/JAD-220276DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro-and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. Results: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro-and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. Conclusion: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Javanshiri, KeivanLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ke2212ja
(author)
-
Haglund, MattiasLund University(Swepub:lu)pat-mh0
(author)
-
Saenz-Sardá, XavierLund University
(author)
-
Englund, ElisabetLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-een
(author)
-
Lund UniversityPatologi, Lund
(creator_code:org_t)
Related titles
-
In:Journal of Alzheimer's Disease89:2, s. 463-4711387-2877
Internet link
Find in a library
To the university's database