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Improving human papillomavirus (HPV) testing in the cervical cancer elimination era : The 2021 HPV LabNet international proficiency study
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- Arroyo Mühr, Laila Sara (author)
- Karolinska Institutet,Karolinska Institute
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- Eklund, Carina (author)
- Karolinska Institutet,Karolinska Institute
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- Lagheden, Camilla (author)
- Karolinska Institutet,Karolinska Institute
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- (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
- In: Journal of Clinical Virology. - : Elsevier BV. - 1386-6532. ; 154, s. 105237-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: Proficient Human Papillomavirus (HPV) genotyping services are essential to support HPV and cervical cancer elimination strategies, in particular to support HPV vaccine research. Objectives: To perform a global HPV genotyping proficiency study, with evaluation in relation to previous proficiency studies. Study design: The proficiency panel contained 44 coded samples (40 samples containing one or more purified HPV types (HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59/68a/68b) in human DNA, 1 human DNA control and 3 DNA extraction controls). Proficiency required detection of both single and multiple infections of 50 International Units of HPV 16/18, of 500 genome equivalents for other HPV types and no false positivity. Results: One hundred and thirty-two laboratories submitted 211 datasets. Most assays used (182/211 datasets) were commercially available. An all-time high of 75% of the datasets were 100% proficient. One or more false positives were found in 17.5% of datasets. Among laboratories who participated in the 2019 proficiency study, full proficiency increased from 25% in 2019 to 60% in 2021. The high overall proficiency was mostly attributable to a large number of new laboratories, which used similar assays. Conclusions: The worldwide deterioration in comparability and reliability of HPV testing found in 2019 is now reversed and an overall increase in proficiency is found.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Cancer eradication
- Cervical cancer
- Human papillomavirus
- International standards
- Quality assurance
Publication and Content Type
- art (subject category)
- ref (subject category)
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