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  • Sanllorente, AlbertCarlos III Health Institute,Hospital del Mar Medical Research Institute,Pompeu Fabra University (author)

A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function : a substudy of the PREDIMED-Plus randomized controlled trial

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021
  • 9 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:63e387f8-6cbe-4bad-92a1-582ac6a90b50
  • https://lup.lub.lu.se/record/63e387f8-6cbe-4bad-92a1-582ac6a90b50URI
  • https://doi.org/10.1093/ajcn/nqab246DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce. OBJECTIVES: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. METHODS: In 391 older adults with metabolic syndrome (mean age, 65 years; mean BMI, 33.3 kg/m2) from 1 of the Prevención con Dieta Mediterránea-Plus trial centers, we evaluated the impact of a 6-month intervention with an energy-restricted Mediterranean diet plus physical activity (intensive lifestyle; n = 190) relative to a nonrestrictive Mediterranean diet without physical activity (control; n = 201) on a set of HDL functional traits. These included cholesterol efflux capacity, HDL oxidative/inflammatory index, HDL oxidation, and levels of complement component 3, serum amyloid A, sphingosine-1-phosphate, triglycerides, and apolipoproteins A-I, A-IV, C-III, and E in apoB-depleted plasma. RESULTS: The intensive-lifestyle intervention participants displayed greater 6-month weight reductions (-3.83 kg; 95% CI: -4.57 to -3.09 kg) but no changes in HDL cholesterol compared with control-diet participants. Regarding HDL functional traits, the intensive lifestyle decreased triglyceride levels (-0.15 mg/g protein; 95% CI: -0.29 to -0.014 mg/g protein) and apoC-III (-0.11 mg/g protein; 95% CI: -0.18 to -0.026 mg/g protein) compared to the control diet, with weight loss being the essential mediator (proportions of mediation were 77.4% and 72.1% for triglycerides and apoC-III levels in HDL, respectively). CONCLUSIONS: In older adults with metabolic syndrome, an energy-restricted Mediterranean diet plus physical activity improved the HDL triglyceride metabolism compared with a nonrestrictive Mediterranean diet without physical activity. This trial is registered at isrctn.com as ISRCTN89898870.

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  • Soria-Florido, María TrinidadLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ma3310so (author)
  • Castañer, OlgaHospital del Mar Medical Research Institute,Carlos III Health Institute (author)
  • Lassale, CamilleCarlos III Health Institute,Hospital del Mar Medical Research Institute (author)
  • Salas-Salvadó, JordiCarlos III Health Institute,Rovira i Virgili University (URV) (author)
  • Martínez-González, Miguel ÁngelCarlos III Health Institute,University of Navarra,Harvard University (author)
  • Subirana, IsaacHospital del Mar Medical Research Institute,Carlos III Health Institute (author)
  • Ros, EmilioInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Carlos III Health Institute,Hospital Clínic of Barcelona (author)
  • Corella, DoloresUniversity of Valencia,Carlos III Health Institute (author)
  • Estruch, RamónCarlos III Health Institute,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona (author)
  • Tinahones, Francisco J.Carlos III Health Institute,University of Malaga (author)
  • Hernáez, ÁlvaroInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Norwegian Institute of Public Health,Carlos III Health Institute,Ramon Llull University (author)
  • Fitó, MontserratHospital del Mar Medical Research Institute,Carlos III Health Institute (author)
  • Carlos III Health InstituteHospital del Mar Medical Research Institute (creator_code:org_t)

Related titles

  • In:The American journal of clinical nutrition: Elsevier BV114:5, s. 1666-16741938-32070002-9165

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