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Production of Cysta...
Production of Cystatin C Wild Type and Stabilized Mutants
- Article/chapterEnglish2010
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LIBRIS-ID:oai:lup.lub.lu.se:640ac852-1071-4ed3-b7de-ccfdca16f689
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https://lup.lub.lu.se/record/640ac852-1071-4ed3-b7de-ccfdca16f689URI
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Language:English
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Summary in:English
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Cystatin C is produced in all nucleated cells. It has various functions and biological activities. Researchers are focused on its role in kidney diseases as a marker of glomerular filtration but also as a very important link in development of amyloid diseases. This work describes expression and purification of both wild type (wt) and stabilized form (stab 1 and 2) of wt cystatin C and amyloid-forming L68Q mutant of cystatin C. The recombinant cystatin C can be used in projects requiring pure cystatin C to examine models of dimerization and fibrils formation as well as a standard in clinical tests.
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Szymanska, Aneta
(author)
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Lindström, VeronicaLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-vli
(author)
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Grubb, AndersLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-agr
(author)
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Avdelningen för klinisk kemi och farmakologiInstitutionen för laboratoriemedicin
(creator_code:org_t)
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In:EJIFCC20:4, s. 70-1661650-3414
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