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The same sequence v...
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
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Helgadottir, Anna (author)
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Thorleifsson, Gudmar (author)
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Magnusson, Kristinn P. (author)
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show more...
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Gretarsdottir, Solveig (author)
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Steinthorsdottir, Valgerdur (author)
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Manolescu, Andrei (author)
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Jones, Gregory T. (author)
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Rinkel, Gabriel J. E. (author)
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Blankensteijn, Jan D. (author)
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Ronkainen, Antti (author)
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Jaaskelainen, Juha E. (author)
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Kyo, Yoshiki (author)
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Lenk, Guy M. (author)
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Sakalihasan, Natzi (author)
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- Kostulas, Konstantinos (author)
- Karolinska Institutet
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- Gottsäter, Anders (author)
- Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
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Flex, Andrea (author)
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Stefansson, Hreinn (author)
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Hansen, Torben (author)
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Andersen, Gitte (author)
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Weinsheimer, Shantel (author)
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Borch-Johnsen, Knut (author)
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Jorgensen, Torben (author)
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Shah, Svati H. (author)
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Quyyumi, Arshed A. (author)
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Granger, Christopher B. (author)
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Reilly, Muredach P. (author)
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Austin, Harland (author)
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Levey, Allan I. (author)
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Vaccarino, Viola (author)
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Palsdottir, Ebba (author)
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Walters, G. Bragi (author)
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Jonsdottir, Thorbjorg (author)
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Snorradottir, Steinunn (author)
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Magnusdottir, Dana (author)
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Gudmundsson, Gudmundur (author)
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Ferrell, Robert E. (author)
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Sveinbjornsdottir, Sigurlaug (author)
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Hernesniemi, Juha (author)
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Niemela, Mika (author)
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Limet, Raymond (author)
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Andersen, Karl (author)
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Sigurdsson, Gunnar (author)
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Benediktsson, Rafn (author)
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Verhoeven, Eric L. G. (author)
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Teijink, Joep A. W. (author)
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Grobbee, Diederick E. (author)
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Rader, Daniel J. (author)
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Collier, David A. (author)
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Pedersen, Oluf (author)
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Pola, Roberto (author)
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- Hillert, Jan (author)
- Karolinska Institutet
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Lindblad, Bengt (author)
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Valdimarsson, Einar M. (author)
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Magnadottir, Hulda B. (author)
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Wijmenga, Cisca (author)
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Tromp, Gerard (author)
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Baas, Annette F. (author)
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Ruigrok, Ynte M. (author)
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van Rij, Andre M. (author)
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Kuivaniemi, Helena (author)
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Powell, Janet T. (author)
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Matthiasson, Stefan E. (author)
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Gulcher, Jeffrey R. (author)
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Thorgeirsson, Gudmundur (author)
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Kong, Augustine (author)
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Thorsteinsdottir, Unnur (author)
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Stefansson, Kari (author)
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(creator_code:org_t)
- 2008-01-06
- 2008
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:2, s. 217-224
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Helgadottir, Ann ...
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Thorleifsson, Gu ...
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Magnusson, Krist ...
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Gretarsdottir, S ...
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Steinthorsdottir ...
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Manolescu, Andre ...
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show more...
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Jones, Gregory T ...
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Rinkel, Gabriel ...
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Blankensteijn, J ...
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Ronkainen, Antti
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Jaaskelainen, Ju ...
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Kyo, Yoshiki
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Lenk, Guy M.
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Sakalihasan, Nat ...
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Kostulas, Konsta ...
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Gottsäter, Ander ...
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Flex, Andrea
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Stefansson, Hrei ...
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Hansen, Torben
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Andersen, Gitte
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Weinsheimer, Sha ...
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Borch-Johnsen, K ...
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Jorgensen, Torbe ...
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Shah, Svati H.
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Quyyumi, Arshed ...
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Granger, Christo ...
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Reilly, Muredach ...
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Austin, Harland
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Levey, Allan I.
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Vaccarino, Viola
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Palsdottir, Ebba
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Walters, G. Brag ...
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Jonsdottir, Thor ...
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Snorradottir, St ...
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Magnusdottir, Da ...
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Gudmundsson, Gud ...
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Ferrell, Robert ...
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Sveinbjornsdotti ...
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Hernesniemi, Juh ...
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Niemela, Mika
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Limet, Raymond
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Andersen, Karl
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Sigurdsson, Gunn ...
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Benediktsson, Ra ...
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Verhoeven, Eric ...
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Teijink, Joep A. ...
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Grobbee, Diederi ...
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Rader, Daniel J.
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Collier, David A ...
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Pedersen, Oluf
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Pola, Roberto
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Hillert, Jan
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Lindblad, Bengt
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Valdimarsson, Ei ...
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Magnadottir, Hul ...
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Wijmenga, Cisca
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Tromp, Gerard
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Baas, Annette F.
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Ruigrok, Ynte M.
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van Rij, Andre M ...
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Kuivaniemi, Hele ...
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Powell, Janet T.
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Matthiasson, Ste ...
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Gulcher, Jeffrey ...
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Thorgeirsson, Gu ...
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Kong, Augustine
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Thorsteinsdottir ...
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet