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Genome-wide mRNA pr...
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease
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- Dwivedi, Om Prakash (author)
- University of Helsinki
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- Barreiro, Karina (author)
- University of Helsinki
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- Käräjämäki, Annemari (author)
- Vaasa Health Care Center
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- Valo, Erkka (author)
- Folkhälsan Research Center
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- Giri, Anil K. (author)
- University of Helsinki
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- Prasad, Rashmi B. (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Roy, Rishi Das (author)
- University of Helsinki
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- Thorn, Lena M. (author)
- Folkhälsan Research Center
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- Rannikko, Antti (author)
- University of Helsinki
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- Holthöfer, Harry (author)
- University of Helsinki
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- Gooding, Kim M. (author)
- University of Exeter
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Sourbron, Steven (author)
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Delic, Denis (author)
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- Gomez, Maria F. (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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Groop, Per-Henrik (author)
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki,Folkhälsan Research Center
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Forsblom, Carol (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
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Puhka, Maija (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: iScience. - 2589-0042. ; 26:5
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly showed >10,000 mRNAs with similarity to kidney transcriptome. T1D DKD groups showed 13 upregulated genes prevalently expressed in proximal tubules, correlated with hyperglycemia and involved in cellular/oxidative stress homeostasis. We used six of them (GPX3, NOX4, MSRB, MSRA, HRSP12 and CRYAB) to construct a transcriptional “stress score” that reflected long-term decline of kidney function and could even identify normoalbuminuric individuals showing early decline. We thus provide workflow and web-resource for studying uEV transcriptomes in clinical urine samples and stress-linked DKD markers as potential early non-invasive biomarkers or drug targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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iScience
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- By the author/editor
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Dwivedi, Om Prak ...
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Barreiro, Karina
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Käräjämäki, Anne ...
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Valo, Erkka
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Giri, Anil K.
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Prasad, Rashmi B ...
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show more...
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Roy, Rishi Das
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Thorn, Lena M.
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Rannikko, Antti
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Holthöfer, Harry
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Gooding, Kim M.
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Sourbron, Steven
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Delic, Denis
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Gomez, Maria F.
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Groop, Per-Henri ...
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Tuomi, Tiinamaij ...
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Forsblom, Carol
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Groop, Leif
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Puhka, Maija
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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iScience
- By the university
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Lund University