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Genome-wide mRNA pr...
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Dwivedi, Om PrakashUniversity of Helsinki
(author)
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease
- Article/chapterEnglish2023
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LIBRIS-ID:oai:lup.lub.lu.se:65011b76-a279-4b40-8e82-3ef0bcbaf801
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https://lup.lub.lu.se/record/65011b76-a279-4b40-8e82-3ef0bcbaf801URI
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https://doi.org/10.1016/j.isci.2023.106686DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Urinary extracellular vesicles (uEV) are a largely unexplored source of kidney-derived mRNAs with potential to serve as a liquid kidney biopsy. We assessed ∼200 uEV mRNA samples from clinical studies by genome-wide sequencing to discover mechanisms and candidate biomarkers of diabetic kidney disease (DKD) in Type 1 diabetes (T1D) with replication in Type 1 and 2 diabetes. Sequencing reproducibly showed >10,000 mRNAs with similarity to kidney transcriptome. T1D DKD groups showed 13 upregulated genes prevalently expressed in proximal tubules, correlated with hyperglycemia and involved in cellular/oxidative stress homeostasis. We used six of them (GPX3, NOX4, MSRB, MSRA, HRSP12 and CRYAB) to construct a transcriptional “stress score” that reflected long-term decline of kidney function and could even identify normoalbuminuric individuals showing early decline. We thus provide workflow and web-resource for studying uEV transcriptomes in clinical urine samples and stress-linked DKD markers as potential early non-invasive biomarkers or drug targets.
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Barreiro, KarinaUniversity of Helsinki
(author)
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Käräjämäki, AnnemariVaasa Health Care Center
(author)
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Valo, ErkkaFolkhälsan Research Center
(author)
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Giri, Anil K.University of Helsinki
(author)
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Prasad, Rashmi B.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-rpa
(author)
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Roy, Rishi DasUniversity of Helsinki
(author)
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Thorn, Lena M.Folkhälsan Research Center
(author)
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Rannikko, AnttiUniversity of Helsinki
(author)
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Holthöfer, HarryUniversity of Helsinki
(author)
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Gooding, Kim M.University of Exeter
(author)
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Sourbron, Steven
(author)
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Delic, Denis
(author)
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Gomez, Maria F.Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)mphy-mgo
(author)
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Groop, Per-Henrik
(author)
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Tuomi, TiinamaijaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki,Folkhälsan Research Center(Swepub:lu)ti8736tu
(author)
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Forsblom, Carol
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(author)
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Puhka, Maija
(author)
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University of HelsinkiVaasa Health Care Center
(creator_code:org_t)
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Dwivedi, Om Prak ...
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Barreiro, Karina
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Käräjämäki, Anne ...
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Valo, Erkka
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Giri, Anil K.
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Prasad, Rashmi B ...
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Roy, Rishi Das
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Thorn, Lena M.
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Rannikko, Antti
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Holthöfer, Harry
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Gooding, Kim M.
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Sourbron, Steven
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Delic, Denis
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Gomez, Maria F.
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Groop, Per-Henri ...
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Tuomi, Tiinamaij ...
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Forsblom, Carol
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Groop, Leif
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Puhka, Maija
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