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Thrombotic disease ...
Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation
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- Nilsson Ekdahl, Kristina (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Klinisk immunologi,Kaskadsystem och biomaterial
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- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Andersson, Jonas (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Klinisk immunologi,Kaskadsystem och biomaterial
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- Elgue, Graciela (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Klinisk immunologi,Kaskadsystem och biomaterial
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- Ronnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Nilsson, Bo (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Klinisk immunologi,Kaskadsystem och biomaterial
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(creator_code:org_t)
- 2004-02-20
- 2004
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048. ; 125, s. 74-
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Abstract
Subject headings
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- Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- systemic lupus erythematosus
- thrombosis
- activation
- platelet
- beta-thromboglobulin
- extracellular phosphorylation
Publication and Content Type
- art (subject category)
- ref (subject category)
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