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Regional transport ...
Regional transport and metabolism of roivacaine and its CYP3A4 metabolite PPX in human intestine
- Article/chapterEnglish2003
Publisher, publication year, extent ...
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2010-02-18
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Oxford University Press (OUP),2003
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:657577e1-2b6c-4df4-90bd-c67281a8ac9f
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https://lup.lub.lu.se/record/303417URI
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https://doi.org/10.1211/0022357021495DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The major aim of this study was to investigate the CYP3A4 metabolism and polarized transport of ropivacaine and its metabolite 2',6'-pipecoloxylidide (PPX) in tissue specimens from the human small and large intestine. Ropivacaine has been shown to be effective in the treatment of ulcerative colitis in human colon. This study was conducted using a modified Ussing-chamber technique with specimens from jejunum, ileum and colon collected from 11 patients. The local kinetics of ropivacaine and PPX were assessed from their concentration-time profiles in mucosal and serosal compartments. The permeability (P-app) in the absorptive direction for both ropivacaine and PPX increased regionally in the order jejunum
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lennernas, P
(author)
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Ekelund, MatsLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-mek
(author)
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Weström, BjörnLund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science(Swepub:lu)zoof-bwe
(author)
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Hoogstraate, J
(author)
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Lennernas, H
(author)
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Kirurgi, LundSektion V
(creator_code:org_t)
Related titles
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In:Journal of Pharmacy and Pharmacology: Oxford University Press (OUP)55:7, s. 963-9720022-35732042-7158
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