Regional transport and metabolism of roivacaine and its CYP3A4 metabolite PPX in human intestine

The major aim of this study was to investigate the CYP3A4 metabolism and polarized transport of ropivacaine and its metabolite 2',6'-pipecoloxylidide (PPX) in tissue specimens from the human small and large intestine. Ropivacaine has been shown to be effective in the treatment of ulcerative colitis in human colon. This study was conducted using a modified Ussing-chamber technique with specimens from jejunum, ileum and colon collected from 11 patients. The local kinetics of ropivacaine and PPX were assessed from their concentration-time profiles in mucosal and serosal compartments. The permeability (P-app) in the absorptive direction for both ropivacaine and PPX increased regionally in the order jejunum

Lennernas, P (author)
Ekelund, MatsLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-mek (author)
Weström, BjörnLund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science(Swepub:lu)zoof-bwe (author)
Hoogstraate, J (author)
Lennernas, H (author)
Kirurgi, LundSektion V (creator_code:org_t)

In:Journal of Pharmacy and Pharmacology: Oxford University Press (OUP)55:7, s. 963-9720022-35732042-7158

By the author/editor: Berggren, S; Lennernas, P; Ekelund, Mats; Weström, Björn; Hoogstraate, J; Lennernas, H

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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