Search: onr:"swepub:oai:lup.lub.lu.se:65920b72-5933-45f1-8c72-ca32f07e1cb0" >
Hyaluronan in Non-S...
Hyaluronan in Non-Surgical and Surgical Periodontal Therapy. A Systematic Review.
-
- Bertl, Kristina (author)
- Malmö högskola,Odontologiska fakulteten (OD)
-
Bruckmann, Corinna (author)
-
- Isberg, Per-Erik (author)
- Lund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM
-
show more...
-
- Klinge, Björn (author)
- Karolinska Institutet,Malmö högskola,Odontologiska fakulteten (OD)
-
Gotfredsen, Klaus (author)
-
- Stavropoulos, Andreas (author)
- Malmö högskola,Odontologiska fakulteten (OD)
-
show less...
-
(creator_code:org_t)
- 2015-03-09
- 2015
- English.
-
In: Journal of Clinical Periodontology. - : Wiley. - 1600-051X .- 0303-6979. ; 42:3, s. 236-246
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- AIM: To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy. METHODS: Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) preclinical in-vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinically. RESULTS: Two preclinical in-vivo studies on surgical treatment and 12 clinical trials on non-surgical and/or surgical treatment were included. Most of the studies were highly heterogeneous, regarding with HY product used and application mode, and of high risk of bias, thus not allowing meta-analysis. The majority of clinical studies described a beneficial, occasionally statistically significant, effect of HY on bleeding on probing (BoP) and pocket depth (PD) reduction (2.28-19.5% and 0.2-0.9mm, respectively), comparing to controls; no adverse effects were reported. CONCLUSIONS: HY application as adjunct to non-surgical and surgical periodontal treatment seems to have a beneficial, generally moderate, effect on surrogate outcome variables of periodontal inflammation, i.e., BoP and residual PD, and appears to be safe. The large heterogeneity of included studies, does not allow recommendations on the mode of application or effect size of HY as adjunct to non-surgical and surgical periodontal treatment.
Subject headings
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- clinical trials
- hyaluronan
- hyaluronate
- hyaluronic acid
- periodontitis
- systematic review
- clinical trials
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database