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- Andersson, SvenLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide
- Article/chapterEnglish1992
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- 1992
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- LIBRIS-ID:oai:lup.lub.lu.se:65d68ba5-d10f-4d3f-be37-ba76ff6e78f7
- https://lup.lub.lu.se/record/1106913URI
- https://doi.org/10.1016/0014-2999(92)94823-EDOI
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- Language:English
- Summary in:English
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- Calcitonin gene-related peptide (CGRP) given i.v. to rabbits induced hypotension and a breakdown of the blood-aqueous barrier. Glibenclamide, a blocker of ATP-sensitive K+ (K+ATP) channels antagonized both these effects. The K+ATP channel opener diazoxide reduced blood pressure but did not damage the blood-aqueous barrier. Inhibition of nitric oxide synthase antagonized the effects of CGRP on the blood-aqueous barrier but did not attenuate the hypotensive response. The results suggest that vasodilatation induced by the opening of K+ATP channels is a prerequisite for the effect of CGRP on the blood-aqueous barrier.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- K+ channels (ATP-sensitive)
- Blood-aqueous barrier
- Nitric oxide (NO)
- Vasodilatation
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- Medicin, LundSektion II (creator_code:org_t)
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- In:European Journal of Pharmacology224:1, s. 89-911879-0712
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