Search: onr:"swepub:oai:lup.lub.lu.se:66601380-806f-4049-a03e-b9a076380bb3" >
TCF7L2 Polymorphism...
TCF7L2 Polymorphism, Weight Loss and Proinsulin: Insulin Ratio in the Diabetes Prevention Program
-
McCaffery, Jeanne M. (author)
-
Jablonski, Kathleen A. (author)
-
- Franks, Paul (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
show more...
-
Dagogo-Jack, Sam (author)
-
Wing, Rena R. (author)
-
Knowler, William C. (author)
-
Delahanty, Linda (author)
-
Dabelea, Dana (author)
-
Hamman, Richard (author)
-
Shuldiner, Alan R. (author)
-
Florez, Jose C. (author)
-
show less...
-
(creator_code:org_t)
- 2011-07-26
- 2011
- English.
-
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:7
- Related links:
-
https://portal.resea... (primary) (free)
-
show more...
-
http://dx.doi.org/10... (free)
-
https://journals.plo...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Aims: TCF7L2 variants have been associated with type 2 diabetes, body mass index (BMI), and deficits in proinsulin processing and insulin secretion. Here we sought to test whether these effects were apparent in high-risk individuals and modify treatment responses. Methods: We examined the potential role of the TCF7L2 rs7903146 variant in predicting resistance to weight loss or a lack of improvement of proinsulin processing during 2.5-years of follow-up participants (N = 2,994) from the Diabetes Prevention Program (DPP), a randomized controlled trial designed to prevent or delay diabetes in high-risk adults. Results: We observed no difference in the degree of weight loss by rs7903146 genotypes. However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P, 0.001), higher baseline proinsulin: insulin ratio (p<0.0001) and increased proinsulin: insulin ratio over a median of 2.5 years of follow-up (P = 0.003). Effects were comparable across treatment arms. Conclusions: The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin: insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
PLoS ONE
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
McCaffery, Jeann ...
-
Jablonski, Kathl ...
-
Franks, Paul
-
Dagogo-Jack, Sam
-
Wing, Rena R.
-
Knowler, William ...
-
show more...
-
Delahanty, Linda
-
Dabelea, Dana
-
Hamman, Richard
-
Shuldiner, Alan ...
-
Florez, Jose C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
PLoS ONE
- By the university
-
Lund University