Search: onr:"swepub:oai:lup.lub.lu.se:66aeecd5-f809-42e2-8715-390a047dbc63" >
Trypanocidal diaryl...
Trypanocidal diarylheptanoids from Aframomum letestuianum K. Schum (Zingiberaceae).
-
Kamnaing, P (author)
-
- Tsopmo, Apollinaire (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
Tanifum, E A (author)
-
show more...
-
Tchuendem, M H K (author)
-
Tane, P (author)
-
Ayafor, J F (author)
-
- Sterner, Olov (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
Rattendi, D (author)
-
Iwu, M M (author)
-
Schuster, B (author)
-
Bacchi, C (author)
-
show less...
-
(creator_code:org_t)
- 2003-02-19
- 2003
- English.
-
In: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 66:3, s. 364-367
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC50 values in the range of 1-3 g/mL were found for compounds 3 and 5.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kamnaing, P
-
Tsopmo, Apollina ...
-
Tanifum, E A
-
Tchuendem, M H K
-
Tane, P
-
Ayafor, J F
-
show more...
-
Sterner, Olov
-
Rattendi, D
-
Iwu, M M
-
Schuster, B
-
Bacchi, C
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Organic Chemistr ...
- Articles in the publication
-
Journal of Natur ...
- By the university
-
Lund University