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Chemokine CXCL13 is...
Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
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van de Pavert, Serge A. (author)
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Olivier, Brenda J. (author)
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Goverse, Gera (author)
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Vondenhoff, Mark F. (author)
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Greuter, Mascha (author)
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Beke, Patrick (author)
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Kusser, Kim (author)
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Hoepken, Uta E. (author)
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Lipp, Martin (author)
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Niederreither, Karen (author)
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Blomhoff, Rune (author)
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- Sitnik, Katarzyna (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Agace, William (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Randall, Troy D. (author)
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de Jonge, Wouter J. (author)
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Mebius, Reina E. (author)
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(creator_code:org_t)
- 2009-09-27
- 2009
- English.
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In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 10:11, s. 78-1193
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Abstract
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- The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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van de Pavert, S ...
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Olivier, Brenda ...
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Goverse, Gera
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Vondenhoff, Mark ...
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Greuter, Mascha
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Beke, Patrick
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show more...
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Kusser, Kim
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Hoepken, Uta E.
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Lipp, Martin
-
Niederreither, K ...
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Blomhoff, Rune
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Sitnik, Katarzyn ...
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Agace, William
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Randall, Troy D.
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de Jonge, Wouter ...
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Mebius, Reina E.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Nature Immunolog ...
- By the university
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Lund University