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Search: onr:"swepub:oai:lup.lub.lu.se:67b3dd8f-eadc-4e1f-b0e1-b87fbff134d7" > A broad spectrum an...

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A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Rao, Komal Umashankar (author)
Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden
Henderson, Domhnall Iain (author)
Lund University, Sweden,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.
Krishnan, Nitya (author)
Imperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
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Puthia, Manoj (author)
Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Inst Clin Sci, Dept Dermatol & Venereol, Lund, Sweden.,Lund University, Sweden
Glegola-Madejska, Izabela (author)
Imperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
Brive, Lena (author)
RISE,Tillverkningsprocesser
Bjarnemark, Fanny (author)
RISE,Kemi, biomaterial och textil,Kemi och Tillämpad mekanik
Millqvist-Fureby, Anna (author)
RISE,Kemiska processer och läkemedel
Hjort, Karin (author)
Uppsala universitet,Uppsala University,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University, Sweden
Andersson, Dan I. (author)
Uppsala universitet,Uppsala University,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University, Sweden
Tenland, Erik (author)
Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden
Sturegård, Erik (author)
Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Lund Univ, Inst Translat Med, Dept Clin Microbiol, Malmö, Sweden.,Lund University, Sweden
Robertson, Brian D. (author)
Imperial College London,Imperial Coll, Dept Infect Dis, MRC Ctr Mol Bacteriol & Infect, London, England.,Imperial College, UK
Godaly, Gabriela (author)
Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Inst Lab Med, Dept Microbiol Immunol & Glycobiol, Lund, Sweden.,Lund University, Sweden
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 (creator_code:org_t)
2021-02-18
2021
English.
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1
Related links:
http://dx.doi.org/10... (free)
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https://www.nature.c...
https://doi.org/10.1...
https://uu.diva-port... (primary) (Raw object)
https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Alternative ways to prevent and treat infectious diseases are needed. Previously, we identified a fungal peptide, NZX, that was comparable to rifampicin in lowering M. tuberculosis load in a murine tuberculosis (TB) infection model. Here we assessed the potential synergy between this cationic host defence peptide (CHDP) and the current TB drugs and analysed its pharmacokinetics. We found additive effect of this peptide with isoniazid and ethambutol and confirmed these results with ethambutol in a murine TB-model. In vivo, the peptide remained stable in circulation and preserved lung structure better than ethambutol alone. Antibiotic resistance studies did not induce mutants with reduced susceptibility to the peptide. We further observed that this peptide was effective against nontuberculous mycobacteria (NTM), such as M. avium and M. abscessus, and several Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In conclusion, the presented data supports a role for this CHDP in the treatment of drug resistant organisms.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

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