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P2Y12 receptor inhi...
P2Y12 receptor inhibitors in patients with non-STelevation acute coronary syndrome in the real world : Use, patient selection, and outcomes from contemporary European registries
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- Zeymer, Uwe (author)
- Klinikum Ludwigshafen
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- Widimsky, Petr (author)
- Charles University in Prague
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- Danchin, Nicolas (author)
- Hôpital Européen Georges-Pompidou
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- Lettino, Maddalena (author)
- Humanitas Research Hospital
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- Bardaji, Alfredo (author)
- Hospital Joan XXIII
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- Barrabes, Jose A. (author)
- Vall d'Hebron University Hospital
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- Cequier, Angel (author)
- Bellvitge University Hospital-IDIBELL
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- Claeys, Marc J. (author)
- Antwerp University Hospital
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- De Luca, Leonardo (author)
- European Hospital
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- Dörler, Jakob (author)
- Medical University of Innsbruck
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Erne, Paul (author)
- University of Zurich
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- Goldstein, Patrick (author)
- Lille University Hospital
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- Koul, Sasha M. (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Lemesle, Gilles (author)
- Lille University Hospital
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- Lüscher, Thomas F. (author)
- University of Zurich
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- Matter, Christian M. (author)
- University of Zurich
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- Montalescot, Gilles (author)
- Pitié-Salpêtrière University Hospital
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- Radovanovic, Dragana (author)
- University of Zurich
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- Sendón, Jose Lopez (author)
- University Hospital La Paz
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- Tousek, Petr (author)
- Charles University in Prague
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- Weidinger, Franz (author)
- Hospital Rudolfstiftung
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- Weston, Clive F.M. (author)
- Swansea University
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- Zaman, Azfar (author)
- Freeman Hospital
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- Andell, Pontus (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Li, Jin (author)
- University of Zurich
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- Wouter Jukema, J. (author)
- Leiden University Medical Centre
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(creator_code:org_t)
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- 2016-03-02
- 2016
- English 15 s.
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In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press (OUP). - 2055-6837 .- 2055-6845. ; 2:4, s. 229-243
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Aims Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic manner on patient characteristics and outcomes for NSTE-ACS in general, and 6 of these (with 52 173 NSTE-ACS patients) also provided more specific data according to P2Y12 receptor inhibitor used. Unadjusted analyses were performed at the study level, and no formal meta-Analysis was performed due to large heterogeneity between studies in the settings, patient characteristics, and outcome definitions. All-cause death rates across registries ranged from 0.76 to 4.79% in-hospital, from 1.61 to 6.65% at 30 days, from 3.66 to 7.16% at 180 days, and from 3.14 to 9.73% at 1 year. Major bleeding events were reported in up to 2.77% of patients while in hospital (in seven registries), up to 1.08% at 30 days (data from one registry only), and 2.06% at 1 year (one registry). Conclusions There were substantial differences in the use of and patient selection for clopidogrel, prasugrel, and ticagrelor, which were associated with differences in short-And long-Term ischaemic and bleeding events. In future registries, data collection should be performed in a more standardized way with respect to endpoints, definitions, and time points.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute coronary syndromes
- Antiplatelets
- Clopidogrel
- Non-ST-segment elevation
- Observational
- P2Y12 receptor inhibitors
- Prasugrel
- Ticagrelor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Zeymer, Uwe
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Widimsky, Petr
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Danchin, Nicolas
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Lettino, Maddale ...
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Bardaji, Alfredo
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Barrabes, Jose A ...
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show more...
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Cequier, Angel
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Claeys, Marc J.
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De Luca, Leonard ...
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Dörler, Jakob
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Erlinge, David
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Erne, Paul
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Goldstein, Patri ...
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Koul, Sasha M.
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Lemesle, Gilles
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Lüscher, Thomas ...
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Matter, Christia ...
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Montalescot, Gil ...
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Radovanovic, Dra ...
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Sendón, Jose Lop ...
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Tousek, Petr
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Weidinger, Franz
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Weston, Clive F. ...
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Zaman, Azfar
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Andell, Pontus
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Li, Jin
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Wouter Jukema, J ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Lund University