Search: onr:"swepub:oai:lup.lub.lu.se:68e5ee38-bc36-4f42-a894-94ffc11e8174" > A replication study...
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000 | 05854naa a2201021 4500 | |
001 | oai:lup.lub.lu.se:68e5ee38-bc36-4f42-a894-94ffc11e8174 | |
003 | SwePub | |
008 | 160401s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:122131480 | |
024 | 7 | a https://lup.lub.lu.se/record/18686822 URI |
024 | 7 | a https://doi.org/10.1136/ard.2010.1418382 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1221314802 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bossini-Castillo, Lara4 aut |
245 | 1 0 | a A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort |
264 | c 2010-12-27 | |
264 | 1 | b BMJ,c 2011 |
520 | a Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected as genetic markers. Results A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively). Significant association of the four tested variants with patients with limited cutaneous SSc (lcSSc) was revealed (rs1234314 OR 1.22, 95% CI 1.07 to 1.38; rs844644 OR 0.91, 95% CI 0.83 to 0.99; rs844648 OR 1.10, 95% CI 1.01 to 1.20 and rs12039904 OR 1.20, 95% CI 1.09 to 1.33). Association of rs1234314, rs844648 and rs12039904 minor alleles with patients positive for anti-centromere antibodies (ACA) remained significant (OR 1.23, 95% CI 1.10 to 1.37; OR 1.12, 95% CI 1.01 to 1.25; OR 1.22, 95% CI 1.07 to 1.38, respectively). Haplotype analysis confirmed a protective haplotype associated with SSc, lcSSc and ACA positive subgroups (OR 0.88, 95% CI 0.82 to 0.96; OR 0.88, 95% CI 0.80 to 0.96; OR 0.86, 95% CI 0.77 to 0.97, respectively) and revealed a new risk haplotype associated with the same groups of patients (OR 1.14, 95% CI 1.03 to 1.26; OR 1.20, 95% CI 1.08 to 1.35; OR 1.23, 95% CI 1.07 to 1.42, respectively). Conclusions The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Broen, Jasper C. A.4 aut |
700 | 1 | a Simeon, Carmen P.4 aut |
700 | 1 | a Beretta, Lorenzo4 aut |
700 | 1 | a Vonk, Madelon C.4 aut |
700 | 1 | a Ortego-Centeno, Norberto4 aut |
700 | 1 | a Espinosa, Gerard4 aut |
700 | 1 | a Carreira, Patricia4 aut |
700 | 1 | a Teresa Camps, Maria4 aut |
700 | 1 | a Navarrete, Nuria4 aut |
700 | 1 | a Gonzalez-Escribano, Maria F.4 aut |
700 | 1 | a Vicente-Rabaneda, Esther4 aut |
700 | 1 | a Rodriguez, Luis4 aut |
700 | 1 | a Tolosa, Carlos4 aut |
700 | 1 | a Roman-Ivorra, Jose A.4 aut |
700 | 1 | a Gomez-Gracia, Inmaculada4 aut |
700 | 1 | a Garcia-Hernandez, Francisco J.4 aut |
700 | 1 | a Castellvi, Ivan4 aut |
700 | 1 | a Gallego, Maria4 aut |
700 | 1 | a Fernandez-Nebro, Antonio4 aut |
700 | 1 | a Garcia-Portales, Rosa4 aut |
700 | 1 | a Victoria Egurbide, Maria4 aut |
700 | 1 | a Fonollosa, Vicente4 aut |
700 | 1 | a Garcia de la Pena, Paloma4 aut |
700 | 1 | a Pros, Ana4 aut |
700 | 1 | a Gonzalez-Gay, Miguel A.4 aut |
700 | 1 | a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-rhe |
700 | 1 | a Riemekasten, Gabriela4 aut |
700 | 1 | a Witte, Torsten4 aut |
700 | 1 | a Coenen, Marieke J. H.4 aut |
700 | 1 | a Koeleman, Bobby P.4 aut |
700 | 1 | a Houssiau, Frederic4 aut |
700 | 1 | a Smith, Vanessa4 aut |
700 | 1 | a de Keyser, Filip4 aut |
700 | 1 | a Westhovens, Rene4 aut |
700 | 1 | a De Langhe, Ellen4 aut |
700 | 1 | a Voskuyl, Alexandre E.4 aut |
700 | 1 | a Schuerwegh, Annemie J.4 aut |
700 | 1 | a Chee, Meng May4 aut |
700 | 1 | a Madhok, Rajan4 aut |
700 | 1 | a Shiels, Paul4 aut |
700 | 1 | a Fonseca, Carmen4 aut |
700 | 1 | a Denton, Christopher4 aut |
700 | 1 | a Claes, Kathleen4 aut |
700 | 1 | a Padykov, Leonidu Karolinska Institutet4 aut |
700 | 1 | a Nordin, Annikau Karolinska Institutet4 aut |
700 | 1 | a Palm, Oyvind4 aut |
700 | 1 | a Lie, Benedicte A.4 aut |
700 | 1 | a Airo, Paolo4 aut |
700 | 1 | a Scorza, Raffaella4 aut |
700 | 1 | a van Laar, Jacob M.4 aut |
700 | 1 | a Hunzelmann, Nicolas4 aut |
700 | 1 | a Kreuter, Alexander4 aut |
700 | 1 | a Herrick, Ariane4 aut |
700 | 1 | a Worthington, Jane4 aut |
700 | 1 | a Radstake, Timothy R. D. J.4 aut |
700 | 1 | a Martin, Javier4 aut |
700 | 1 | a Rueda, Blanca4 aut |
710 | 2 | a Reumatologi och molekylär skelettbiologib Sektion III4 org |
773 | 0 | t Annals of the Rheumatic Diseasesd : BMJg 70:4, s. 638-641q 70:4<638-641x 1468-2060x 0003-4967 |
856 | 4 | u http://dx.doi.org/10.1136/ard.2010.141838y FULLTEXT |
856 | 4 | u http://eprints.gla.ac.uk/54565/1/ID54565.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1868682 |
856 | 4 8 | u https://doi.org/10.1136/ard.2010.141838 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122131480 |
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