Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches

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Linden, Sara K. (author)

Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches

Article/chapterEnglish2008

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Wiley,2008

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LIBRIS-ID:oai:lup.lub.lu.se:6a06d4cc-2628-4656-97c0-01ead160194a
https://lup.lub.lu.se/record/1193288URI
https://doi.org/10.1111/j.1523-5378.2008.00587.xDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15690URI

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Language:English
Summary in:English

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Background: Helicobacter pylori causes peptic ulcer disease and gastric cancer, and the oral cavity is likely to serve as a reservoir for this pathogen. We investigated the binding of H. pylori to the mucins covering the mucosal surfaces in the niches along the oral to gastric infection route and during gastric disease and modeled the outcome of these interactions. Materials and Methods: A panel of seven H. pylori strains with defined binding properties was used to identify binding to human mucins from saliva, gastric juice, cardia, corpus, and antrum of healthy stomachs and of stomachs affected by gastritis at pH 7.4 and 3.0 using a microtiter-based method. Results: H. pylori binding to mucins differed substantially with the anatomic site, mucin type, pH, gastritis status, and H. pylori strain all having effect on binding. Mucins from saliva and gastric juice displayed the most diverse binding patterns, involving four modes of H. pylori adhesion and the MUC5B, MUC7, and MUC5AC mucins as well as the salivary agglutinin. Binding occurred via the blood-group antigen-binding adhesin (BabA), the sialic acid-binding adhesin (SabA), a charge/low pH-dependent mechanism, and a novel saliva-binding adhesin. In the healthy gastric mucus layer only BabA and acid/charge affect binding to the mucins, whereas in gastritis, the BabA/Le(b)-dependent binding to MUC5AC remained, and SabA and low pH binding increased. Conclusions: The four H. pylori adhesion modes binding to mucins are likely to play different roles during colonization of the oral to gastric niches and during long-term infection.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
bacterial adhesin
glycosylation
Helicobacter pylori
mucin
MUC5B

Added entries (persons, corporate bodies, meetings, titles ...)

Wickström, ClaesMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odclwi (author)
Lindell, GertLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-gli (author)
Gilshenan, Kristen (author)
Carlstedt, IngemarLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)medk-ica (author)
Malmö högskolaOdontologiska fakulteten (OD) (creator_code:org_t)

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In:Helicobacter: Wiley13:2, s. 81-931083-43891523-5378

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By the author/editor: Linden, Sara K.; Wickström, Claes; Lindell, Gert; Gilshenan, Krist ...; Carlstedt, Ingem ...

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