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Regional brain-deri...
Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Nawa, H (author)
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Uchino, H (author)
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- Elmer, Eskil (author)
- Lund University,Lunds universitet,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kokaia, M (author)
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Carnahan, J (author)
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Smith, M L (author)
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Siesjo, B K (author)
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Lindvall, O (author)
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(creator_code:org_t)
- 1996
- 1996
- English.
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In: Brain Research. Molecular Brain Research. - 0169-328X. ; 38:1, s. 139-144
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Levels of BDNF mRNA and protein were measured in the rat brain using in situ hybridization and a two-site enzyme immunoassay. Under basal conditions, the highest BDNF concentration was found in the dentate gyrus (88 ng/g), while the levels in CA3 (50 ng/g), CA1 (18 ng/g) and parietal cortex (8 ng/g) were markedly lower. Following 10 min of forebrain ischemia, BDNF protein increased transiently in the dentate gyrus (to 124% of control at 6 h after the insult) and CA3 region (to 131% of control, at 1 week after the insult). In CA1 and parietal cortex, BDNF protein decreased to 73-75% of control at 24 h. In contrast, BDNF mRNA expression in dentate granule cells and CA3 pyramidal layer was transiently elevated to 287 and 293% of control, respectively, at 2 h, whereas no change was detected in CA1 or neocortex. The regional BDNF protein levels shown here correlate at least partly with regional differences in cellular resistance to ischemic damage, which is consistent with the hypothesis of a neuroprotective role of BDNF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Rat
- Brain damage
- Hippocampus
- Neurotrophins
- Forebrain ischemia
Publication and Content Type
- art (subject category)
- ref (subject category)
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