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Ovarian cancer pred...
Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group
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Timmerman, D. (author)
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Van Calster, B. (author)
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Testa, A. C. (author)
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Guerriero, S. (author)
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Fischerova, D. (author)
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Lissoni, A. A. (author)
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Van Holsbeke, C. (author)
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Fruscio, R. (author)
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Czekierdowski, A. (author)
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Jurkovic, D. (author)
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Savelli, L. (author)
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Vergote, I. (author)
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Bourne, T. (author)
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Van Huffel, S. (author)
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- Valentin, Lil (author)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups
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(creator_code:org_t)
- 2010-03-30
- 2010
- English.
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In: Ultrasound in Obstetrics & Gynecology. - : Wiley. - 1469-0705 .- 0960-7692. ; 36:2, s. 226-234
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http://dx.doi.org/10...
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Abstract
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- Objectives The aims of the study were to temporally and externally validate the diagnostic performance of two logistic regression models containing clinical and ultrasound variables in order to estimate the risk of malignancy in adnexal masses, and to compare the results with the subjective interpretation of ultrasound findings carried out by an experienced ultrasound examiner ('subjective assessment'). Methods Patients with adnexal masses, who were put forward by the 19 centers participating in the study, underwent a standardized transvaginal ultrasound examination by a gynecologist or a radiologist specialized in ultrasonography. The examiner prospectively collected information on clinical and ultrasound variables, and classified each mass as benign or malignant on the basis of subjective evaluation of ultrasound findings. The gold standard was the histology of the mass with local clinicians deciding whether to operate on the basis of ultrasound results and the clinical picture. The models' ability to discriminate between malignant and benign masses was assessed, together with the accuracy of the risk estimates. Results Of the 1938 patients included in the study, 1396 had benign, 373 had primary invasive, 111 had borderline malignant and 58 had metastatic tumors. On external validation (997 patients from 12 centers), the area under the receiver operating characteristics curve (AUC) for a model containing 12 predictors (LR1) was 0.956, for a reduced model with six predictors (LR2) was 0.949 and for subjective assessment was 0.949. Subjective assessment gave a positive likelihood ratio of 11.0 and a negative likelihood ratio of 0.14. The corresponding likelihood ratios for a previously derived probability threshold (0.1) were 6.84 and 0.09 for LR1, and 6.36 and 0.10 for LR2. On temporal validation (941 patients from seven centers), the AUCs were 0.945 (LR1), 0.918 (LR2) and 0.959 (subjective assessment). Conclusions Both models provide excellent discrimination between benign and malignant masses. Because the models provide an objective and reasonably accurate risk estimation, they may improve the management of women with suspected ovarian pathology. Copyright (C) 2010 ISUOG. Published by John Wiley & Sons, Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- ultrasonography
- sensitivity and specificity
- ovarian neoplasms
- color Doppler ultrasonography
- logistic models
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Timmerman, D.
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Van Calster, B.
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Testa, A. C.
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Guerriero, S.
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Fischerova, D.
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Lissoni, A. A.
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show more...
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Van Holsbeke, C.
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Fruscio, R.
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Czekierdowski, A ...
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Jurkovic, D.
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Savelli, L.
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Vergote, I.
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Bourne, T.
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Van Huffel, S.
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Valentin, Lil
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Ultrasound in Ob ...
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Lund University