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Tenascins are assoc...
Tenascins are associated with lipid rafts isolated from mouse brain
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Kappler, J (author)
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Baader, SL (author)
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Franken, S (author)
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Pesheva, P (author)
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Schilling, K (author)
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- Rauch, Uwe (author)
- Lund University,Lunds universitet,Kärlväggsbiologi,Forskargrupper vid Lunds universitet,Vessel Wall Biology,Lund University Research Groups
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Gieselmann, V (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Biochemical and Biophysical Research Communications. - 1090-2104. ; 294:3, s. 742-747
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- Lipid rafts are microdomains of the plasma membrane which are enriched in glycosphingolipids and specific proteins. The reported interactions of several raft-associated proteins (such as, e.g., F3) with tenascin C and tenascin R prompted us to consider that these oligomeric multidomain glycoproteins of the extracellular matrix (ECM) could associate with rafts. Here, we show punctate immunocytochemical distributions of tenascin C (TN-C) and tenascin R (TN-R) at the membrane surface of neural cells resembling the pattern reported for raft-associated proteins. Moreover, cholesterol depletion with methyl-beta-cyclodextrin reduced the punctate surface staining of TN-C. Consistently, TN-C was associated with lipid rafts of neonatal mouse brain according to sucrose density gradient centrifugation experiments. Furthermore, TN-R was also found in rafts prepared from myelin of adult mice. Thus, brain-derived tenascins are able to associate with lipid rafts. (C) 2002 Elsevier Science (USA). All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- cerebellum
- tenascin
- lipid rafts
Publication and Content Type
- art (subject category)
- ref (subject category)
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