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- Persson, PatrikLund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH (author)
Parameter estimation of protein chromatographic processes based on breakthrough curves
- Article/chapterEnglish2002
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- 2002
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- LIBRIS-ID:oai:lup.lub.lu.se:6b127a33-27f4-4f4e-bb57-14c436ab3975
- https://lup.lub.lu.se/record/1407245URI
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- Language:English
- Summary in:English
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- A methodology for parameter estimation in chromatographic models is suggested in this paper, which is based on breakthrough curves from a given column set-up. Physical parameters are found in two subsequent experiments, one for the mobile phase behaviour and one for the stationary phase behaviour. The estimations are based on flow rate changes and multiple responses. Adsorption parameters are found also in two subsequent experiments, one for isotherm parameters and one for kinetics parameters. These estimations are based on concentration changes. The conclusion is that it is possible to estimate the parameters in a general rate model using nonlinear least square estimation and numerical simulation of the model. Copyright (C) 2001 IFAC.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Kemiteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Chemical Engineering hsv//eng
- simulation
- numerical methods
- parameter estimation
- chromatography
- modelling
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- Nilsson, BerntLund University,Lunds universitet,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)kat-bni (author)
- Avdelningen för kemiteknikInstitutionen för processteknik och tillämpad biovetenskap (creator_code:org_t)
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- In:Computer Applications in Biotechnology 2001 (CAB8), s. 113-1180080436811
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