Search: onr:"swepub:oai:lup.lub.lu.se:6b8db3c8-ffa1-44a1-83e6-dc602555666b" >
Altered cytoplasmic...
Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer
-
Brennan, Donal J (author)
-
Rexhepaj, Elton (author)
-
O'Brien, Sallyann L (author)
-
show more...
-
McSherry, Elaine (author)
-
O'Connor, Darran P (author)
-
Fagan, Ailis (author)
-
Culhane, Aedin C (author)
-
Higgins, Desmond G (author)
-
- Jirstrom, Karin (author)
- Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Harvard T.H. Chan School of Public Health,Skåne University Hospital
-
Millikan, Robert C (author)
-
- Landberg, Göran (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
-
Duffy, Michael J (author)
-
Hewitt, Stephen M (author)
-
Gallaghe, William M (author)
-
show less...
-
(creator_code:org_t)
- 2008
- 2008
- English.
-
In: Clinical Cancer Research. - 1078-0432. ; 14:9, s. 2681-2689
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Purpose: Survivin (BIRC5) is a promising tumor biomarker. Conflicting data exist on its prognostic effect in breast cancer. These data may at least be partly due to the manual interpretation of immunohistochemical staining, especially as survivin can be located in both the nucleus and cytoplasm. Quantitative determination of survivin expression using image analysis offers the opportunity to develop alternative scoring models for survivin immunohistochemistry. Here, we present such a model. Experimental Design: A breast cancer tissue microarray containing 102 tumors was stained with an anti-survivin antibody. Whole-slide scanning was used to capture high-resolution images. These images were analyzed using automated algorithms to quantify the staining. Results: Increased nuclear, but not cytoplasmic, survivin was associated with a reduced overall survival (OS; P = 0.038) and disease-specific survival (P = 0.0015). A high cytoplasmicto-nuclear ratio (CNR) of survivin was associated with improved OS (P = 0.005) and disease-specific survival (P = 0.05). Multivariate analysis revealed that the survivin CNR was an independent predictor of CIS (hazard ratio, 0.09; 95% confidence interval, 0.01-0.76; P = 0.027). A survivin CNR of >5 correlated positively with estrogen receptor (P = 0.019) and progesterone receptor (P = 0.033) levels, whereas it was negatively associated with Ki-67 expression (P = 0.04), p53 status (P = 0.005), and c-myc amplification (P = 0.016). Conclusion: Different prognostic information is supplied by nuclear and cytoplasmic survivin in breast cancer. Nuclear survivin is a poor prognostic marker in breast cancer. Moreover, CNR of survivin, as determined by image analysis, is an independent prognostic factor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Brennan, Donal J
-
Rexhepaj, Elton
-
O'Brien, Sallyan ...
-
McSherry, Elaine
-
O'Connor, Darran ...
-
Fagan, Ailis
-
show more...
-
Culhane, Aedin C
-
Higgins, Desmond ...
-
Jirstrom, Karin
-
Millikan, Robert ...
-
Landberg, Göran
-
Duffy, Michael J
-
Hewitt, Stephen ...
-
Gallaghe, Willia ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Clinical Cancer ...
- By the university
-
Lund University