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A clinical primer f...
A clinical primer for the glymphatic system
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- Carlstrom, Lucas P. (author)
- Mayo Clinic Minnesota
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- Eltanahy, Ahmed (author)
- Mayo Clinic Minnesota
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- Perry, Avital (author)
- Mayo Clinic Minnesota
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- Rabinstein, Alejandro A. (author)
- Mayo Clinic Minnesota
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- Elder, Benjamin D. (author)
- Mayo Clinic Minnesota
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- Morris, Jonathan M. (author)
- Mayo Clinic Minnesota
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- Meyer, Fredric B. (author)
- Mayo Clinic Minnesota
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- Graffeo, Christopher S. (author)
- Mayo Clinic Minnesota
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- Lundgaard, Iben (author)
- Lund University,Lunds universitet,Glia-Immune Interactions,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- Burns, Terry C. (author)
- Mayo Clinic Minnesota
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(creator_code:org_t)
- 2021-12-09
- 2022
- English 15 s.
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In: Brain. - : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 145:3, s. 843-857
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Abstract
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- The complex and dynamic system of fluid flow through the perivascular and interstitial spaces of the CNS has new-found implications for neurological diseases. CSF movement throughout the CNS parenchyma is more dynamic than could be explained via passive diffusion mechanisms alone. Indeed, a semistructured glial-lymphatic (glymphatic) system of astrocyte-supported extracellular perivascular channels serves to directionally channel extracellular fluid, clearing metabolites and peptides to optimize neurological function. Clinical studies of the glymphatic network have to date proven challenging, with most data gleaned from rodent models and post-mortem investigations. However, increasing evidence suggests that disordered glymphatic function contributes to the pathophysiology of CNS ageing, neurodegenerative disease and CNS injuries, as well as normal pressure hydrocephalus. Unlocking such pathophysiology could provide important avenues towards novel therapeutics. We here provide a multidisciplinary overview of glymphatics and critically review accumulating evidence regarding its structure, function and hypothesized relevance to neurological disease. We highlight emerging technologies of relevance to the longitudinal evaluation of glymphatic function in health and disease. Finally, we discuss the translational opportunities and challenges of studying glymphatic science.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- aging
- Alzheimer's disease
- beta-amyloid
- glymphatic system
- idiopathic normal pressure hydrocephalus
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Carlstrom, Lucas ...
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Eltanahy, Ahmed
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Perry, Avital
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Rabinstein, Alej ...
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Elder, Benjamin ...
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Morris, Jonathan ...
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Meyer, Fredric B ...
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Graffeo, Christo ...
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Lundgaard, Iben
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Burns, Terry C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Lund University