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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006767naa a2200757 4500
001oai:lup.lub.lu.se:6c8b5eaf-dceb-48d6-b084-bebfddbf1220
003SwePub
008181019s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6c8b5eaf-dceb-48d6-b084-bebfddbf12202 URI
0247 a https://doi.org/10.1212/NXG.00000000000001802 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Giese, Anne Katrinu Broad Institute,Massachusetts General Hospital4 aut
2451 0a Design and rationale for examining neuroimaging genetics in ischemic stroke : The MRI-GENIE study
264 1c 2017
520 a Objective: To describe the design and rationale for the genetic analysis of acute and chronic cerebrovascular neuroimaging phenotypes detected on clinical MRI in patients with acute ischemic stroke (AIS) within the scope of the MRI-GENetics Interface Exploration (MRI-GENIE) study. Methods: MRI-GENIE capitalizes on the existing infrastructure of the Stroke Genetics Network (SiGN). In total, 12 international SiGN sites contributedMRIs of 3,301 patients with AIS. Detailed clinical phenotyping with the web-based Causative Classification of Stroke (CCS) system and genome-wide genotyping data were available for all participants. Neuroimaging analyses include themanual and automated assessments of established MRI markers. A high-throughputMRI analysis pipeline for the automated assessment of cerebrovascular lesions on clinical scans will be developed in a subset of scans for both acute and chronic lesions, validated against gold standard, and applied to all available scans. The extracted neuroimaging phenotypes will improve characterization of acute and chronic cerebrovascular lesions in ischemic stroke, including CCS subtypes, and their effect on functional outcomes after stroke. Moreover, genetic testing will uncover variants associated with acute and chronic MRI manifestations of cerebrovascular disease.Conclusions: The MRI-GENIE study aims to develop, validate, and distribute the MRI analysis platform for scans acquired as part of clinical care for patients with AIS, which will lead to (1) novel genetic discoveries in ischemic stroke, (2) strategies for personalized stroke risk assessment, and (3) personalized stroke outcome assessment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Schirmer, Markus D.u Massachusetts Institute of Technology,Massachusetts General Hospital4 aut
7001 a Donahue, Kathleen L.u Massachusetts General Hospital4 aut
7001 a Cloonan, Lisau Massachusetts General Hospital4 aut
7001 a Irie, Robertu Massachusetts General Hospital4 aut
7001 a Winzeck, Stefanu Massachusetts General Hospital4 aut
7001 a Bouts, Mark J.R.J.u Massachusetts General Hospital4 aut
7001 a McIntosh, Elissa C.u Massachusetts General Hospital4 aut
7001 a Mocking, Steven J.u Massachusetts General Hospital4 aut
7001 a Dalca, Adrian V.u Massachusetts Institute of Technology,Massachusetts General Hospital4 aut
7001 a Sridharan, Rameshu Medical University of Graz4 aut
7001 a Xu, Huichunu University of Maryland, Baltimore4 aut
7001 a Frid, Petreau Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-ptf
7001 a Giralt-Steinhauer, Evau Autonomous University of Barcelona4 aut
7001 a Holmegaard, Lukasu Sahlgrenska Academy4 aut
7001 a Roquer, Jaumeu Massachusetts General Hospital,Broad Institute4 aut
7001 a Wasselius, Johanu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)oft-jws
7001 a Cole, John W.u University of Maryland, Baltimore4 aut
7001 a McArdle, Patrick F.u University of Maryland, Baltimore4 aut
7001 a Broderick, Joseph P.u University of Cincinnati4 aut
7001 a Jimenez-Conde, Jordiu Autonomous University of Barcelona4 aut
7001 a Jern, Christinau Sahlgrenska Academy4 aut
7001 a Kissela, Brett M.u University of Cincinnati4 aut
7001 a Kleindorfer, Dawn O.u University of Cincinnati4 aut
7001 a Lemmens, Robinu University Hospitals Leuven,Catholic University of Leuven,Flanders Interuniversity Institute for Biotechnology4 aut
7001 a Lindgren, Arneu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)neur-ali
7001 a Meschia, James F.u Mayo Clinic Minnesota4 aut
7001 a Rundek, Tatjanau University of Miami4 aut
7001 a Sacco, Ralph L.u Massachusetts General Hospital4 aut
7001 a Schmidt, Reinholdu Massachusetts Institute of Technology4 aut
7001 a Sharma, Pankaju Ashford And St Peter's Hospital,Royal Holloway University of London4 aut
7001 a Slowik, Agnieszkau Jagiellonian University4 aut
7001 a Thijs, Vincentu Austin Health,Florey Institute of Neuroscience and Mental Health4 aut
7001 a Woo, Danielu University of Cincinnati4 aut
7001 a Worrall, Bradford B.u University of Virginia4 aut
7001 a Kittner, Steven J.u University of Maryland, Baltimore4 aut
7001 a Mitchell, Braxton D.u Veterans Health Administration,University of Maryland, Baltimore4 aut
7001 a Rosand, Jonathanu Autonomous University of Barcelona4 aut
7001 a Golland, Polinau Massachusetts Institute of Technology4 aut
7001 a Wu, Onau Massachusetts General Hospital4 aut
7001 a Rost, Natalia S.u Massachusetts General Hospital4 aut
7102 a Broad Instituteb Massachusetts General Hospital4 org
7730 t Neurology: Geneticsg 3:5q 3:5x 2376-7839
8564 u http://dx.doi.org/10.1212/NXG.0000000000000180x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/6c8b5eaf-dceb-48d6-b084-bebfddbf1220
8564 8u https://doi.org/10.1212/NXG.0000000000000180

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