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Comparison of two e...
Comparison of two extraction methods for the determination of selective serotonin reuptake inhibitors in sewage sludge by hollow fiber liquid-phase microextraction
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Sagrista, Ester (author)
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Manuel Cortes, Jose (author)
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- Larsson, Estelle (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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Salvado, Victoria (author)
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Hidalgo, Manuela (author)
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- Jönsson, Jan Åke (author)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2012-07-02
- 2012
- English.
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In: Journal of Separation Science. - : Wiley. - 1615-9314 .- 1615-9306. ; 35:18, s. 2460-2468
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This paper presents two procedures for the determination of four selective serotonin reuptake inhibitors (citalopram, paroxetine, fluoxetine, and sertraline) and one metabolite (norfluoxetine) in sewage sludge utilizing three-phase hollow fiber liquid-phase microextraction (HF-LPME). First, direct HF-LPME was used for extraction, clean-up, and preconcentration. The pharmaceuticals were extracted from slurry samples into an organic phase and then back-extracted into an aqueous phase in the lumen of the hollow fiber. Second, a procedure combining pressurized hot water extraction and HF-LPME for clean-up and preconcentration was developed for the same analytes and matrix. The extracts were subsequently analyzed by liquid chromatographymass spectrometry. For direct HF-LPME, limits of detection were between 1 and 12 ng g-1 (dry weight) and the relative standard deviation (RSD) values were 312%. For the second method, limits of detection were approximately 6 ng g-1 for all the compounds and RSD values were 812%. The methods were validated by comparison of results for the same samples. Sewage sludge from a Swedish wastewater treatment plant was analyzed by both methods; average concentrations were similar for citalopram, paroxetine, and fluoxetine with values of approximately 530, 40, and 200 ng g-1, respectively.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Hollow fiber liquid-phase microextraction
- Pressurized hot water
- extraction
- Selective serotonin reuptake inhibitors
- Sewage sludge
Publication and Content Type
- art (subject category)
- ref (subject category)
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