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Exploring the role ...
Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome
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- Holm Nielsen, S. (author)
- Nordic Bioscience AS,Technical University of Denmark,Nordic Biosci, Denmark; Tech Univ Denmark, Denmark
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- Jonasson, Lena, 1956- (author)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Kalogeropoulos, K. (author)
- Technical University of Denmark,Tech Univ Denmark, Denmark
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- Karsdal, M. A. (author)
- Nordic Bioscience AS,Nordic Biosci, Denmark
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- Reese-Petersen, A. L. (author)
- Nordic Bioscience AS,Nordic Biosci, Denmark
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- auf dem Keller, U. (author)
- Technical University of Denmark,Tech Univ Denmark, Denmark
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- Genovese, F. (author)
- Nordic Bioscience AS,Nordic Biosci, Denmark
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- Nilsson, J. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Lund Univ, Sweden
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- Goncalves, I. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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(creator_code:org_t)
- 2020-03-03
- 2020
- English 21 s.
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In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 287:5, s. 493-513
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Abstract
Subject headings
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- Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- atherosclerosis
- biomarkers
- extracellular matrix
- outcome
- vulnerable plaque
- atherosclerosis; biomarkers; extracellular matrix; outcome; vulnerable plaque
Publication and Content Type
- for (subject category)
- ref (subject category)
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- By the author/editor
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Holm Nielsen, S.
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Jonasson, Lena, ...
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Kalogeropoulos, ...
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Karsdal, M. A.
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Reese-Petersen, ...
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auf dem Keller, ...
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show more...
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Genovese, F.
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Nilsson, J.
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Goncalves, I.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Journal of Inter ...
- By the university
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Lund University
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Linköping University