Search: onr:"swepub:oai:lup.lub.lu.se:6ddb9392-66a3-47fe-8507-d086dce1b12a" >
Sex differences in ...
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Li, Constance H.University of Toronto,University of California, Los Angeles,Ontario Institute for Cancer Research
(author)
Sex differences in oncogenic mutational processes
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-08-28
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Springer Science and Business Media LLC,2020
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24 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:6ddb9392-66a3-47fe-8507-d086dce1b12a
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https://lup.lub.lu.se/record/6ddb9392-66a3-47fe-8507-d086dce1b12aURI
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https://doi.org/10.1038/s41467-020-17359-2DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431727URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145707735URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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CW deltog i PCAWG Consortium.
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Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Prokopec, Stephenie D.Ontario Institute for Cancer Research
(author)
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Sun, Ren X.University of Toronto,Ontario Institute for Cancer Research
(author)
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Yousif, FouadOntario Institute for Cancer Research
(author)
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Schmitz, NathanielOntario Institute for Cancer Research
(author)
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Al-Shahrour, FatimaSpanish National Cancer Research Center (CNIO)
(author)
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Atwal, GurnitUniversity of Toronto,Ontario Institute for Cancer Research
(author)
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Bailey, Peter J.Glasgow Royal Infirmary
(author)
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Biankin, Andrew V.Glasgow Royal Infirmary,University of New South Wales
(author)
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Boutros, Paul C.University of California, Los Angeles,Ontario Institute for Cancer Research,University of Toronto
(author)
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Campbell, Peter J.University of Cambridge,Wellcome Trust Sanger Institute
(author)
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Chang, David K.Glasgow Royal Infirmary,University of New South Wales
(author)
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Cooke, Susanna L.Glasgow Royal Infirmary
(author)
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Deshpande, VikramMassachusetts General Hospital
(author)
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Faltas, Bishoy M.Weill Cornell Medical College
(author)
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Faquin, William C.Massachusetts General Hospital
(author)
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Garraway, LeviDana-Farber Cancer Institute
(author)
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Getz, GadMassachusetts General Hospital,Broad Institute,Harvard Medical School
(author)
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Grimmond, Sean M.University of Melbourne
(author)
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Haider, SyedOntario Institute for Cancer Research
(author)
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Hoadley, Katherine A.University of North Carolina
(author)
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Jiao, WeiOntario Institute for Cancer Research
(author)
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Kaiser, Vera B.University of Edinburgh
(author)
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Karlić, RosaUniversity of Zagreb
(author)
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Kato, MamoruNational Cancer Center Research Institute, Japan
(author)
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Kübler, KirstenMassachusetts General Hospital,Harvard Medical School,Broad Institute
(author)
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Lazar, Alexander J.University of Texas
(author)
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Wright, Derek W.University of Glasgow(Swepub:lu)mbio-dwr
(author)
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Borg, AkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo
(author)
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Davis, Ian J.University of North Carolina(Swepub:lu)bran-iad
(author)
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Ehinger, AnnaLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)pat-amm
(author)
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Glodzik, DominikWellcome Trust Sanger Institute(Swepub:lu)do5123gl
(author)
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Grabau, DortheSkåne University Hospital(Swepub:lu)med-dgu
(author)
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Huang, Mi NiDuke–NUS Medical School(Swepub:lu)hu7785mi
(author)
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Johansson, Peter A.QIMR Berghofer Medical Research Institute
(author)
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Larsson, ErikUniversity of Gothenburg
(author)
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Li, ChangChina National Genebank
(author)
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Li, Haiyan IreneBritish Columbia Cancer Agency(Swepub:lu)endo-hli
(author)
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Li, JunUniversity of Texas
(author)
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Möller, PeterUniversity Hospital of Ulm
(author)
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Ringnér, MarkusLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)thep-mri
(author)
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Song, LeiNational Cancer Institute, USA(Swepub:lu)med-ls1
(author)
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Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Institutionen för kliniska vetenskaper, Lund,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Department of Clinical Sciences, Lund(Swepub:lu)onk-jst
(author)
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Wang, Jian
(author)
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Wang, QiGerman Cancer Research Centre
(author)
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Yang, YangUniversity of Texas
(author)
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Zhang, FanPeking University
(author)
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Zhang, JingYale University
(author)
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Zhang, YanYale University,Ohio State University
(author)
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University of TorontoUniversity of California, Los Angeles
(creator_code:org_t)
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PCAWG Tumour Subtypes and Clinical Translation
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PCAWG Consortium
Related titles
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In:Nature Communications: Springer Science and Business Media LLC112041-1723
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To the university's database
- By the author/editor
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Li, Constance H.
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Prokopec, Stephe ...
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Sun, Ren X.
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Yousif, Fouad
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Schmitz, Nathani ...
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Al-Shahrour, Fat ...
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show more...
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Atwal, Gurnit
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Bailey, Peter J.
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Biankin, Andrew ...
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Boutros, Paul C.
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Campbell, Peter ...
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Chang, David K.
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Cooke, Susanna L ...
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Deshpande, Vikra ...
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Faltas, Bishoy M ...
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Faquin, William ...
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Garraway, Levi
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Getz, Gad
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Grimmond, Sean M ...
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Haider, Syed
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Hoadley, Katheri ...
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Jiao, Wei
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Kaiser, Vera B.
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Karlić, Rosa
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Kato, Mamoru
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Kübler, Kirsten
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Lazar, Alexander ...
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Wright, Derek W.
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Borg, Ake
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Davis, Ian J.
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Ehinger, Anna
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Glodzik, Dominik
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Grabau, Dorthe
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Huang, Mi Ni
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Johansson, Peter ...
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Larsson, Erik
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Li, Chang
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Li, Haiyan Irene
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Li, Jun
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Möller, Peter
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Ringnér, Markus
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Song, Lei
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Staaf, Johan
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Wang, Jian
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Wang, Qi
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Yang, Yang
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Zhang, Fan
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Zhang, Jing
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Zhang, Yan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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Uppsala University
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Karolinska Institutet