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Small intestinal CD...
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Jaensson Gyllenbäck, ElinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
(author)
Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-08-18
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Rockefeller University Press,2008
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LIBRIS-ID:oai:lup.lub.lu.se:6e0287f1-325e-4156-8b9c-0868c99c10ac
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https://lup.lub.lu.se/record/1286676URI
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https://doi.org/10.1084/jem.20080414DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Uronen-Hansson, HeliLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)med-hiu
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Pabst, Oliver
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Eksteen, Bertus
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Tian, Jiong
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Coombes, Janine L.
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Berg, Pia-Lena
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Davidsson, ThomasLund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups(Swepub:lu)urok-tda
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Powrie, Fiona
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Johansson Lindbom, BengtLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)immt-bjo
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Agace, WilliamLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)immu-wag
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ImmunologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Journal of Experimental Medicine: Rockefeller University Press205:9, s. 2139-21491540-95380022-1007
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