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A cross-sectional s...
A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis.
- Article/chapterEnglish2011
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2010-12-13
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Oxford University Press (OUP),2011
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LIBRIS-ID:oai:lup.lub.lu.se:6e2a445e-d48f-4e8a-a352-5258290d9595
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https://lup.lub.lu.se/record/1756400URI
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https://doi.org/10.1093/rheumatology/keq400DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Objective. Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis. Methods. A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decision, CRP and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. Results. WG (63%), Churg-Strauss syndrome (9%) and microscopic polyangiitis (9%) were the most common diagnoses. The BVAS v. 3 showed convergent validity with the VAI [ρ = 0.82 (95% CI 0.77, 0.85)], PGA [ρ = 0.85 (95% CI 0.81, 0.88)] and the physician's treatment decision [ρ = 0.54 (95% CI 0.44, 0.62)]. There was little or no correlation between BVAS v. 3 and the CRP level [ρ = 0.18 (95% CI 0.05, 0.30)] or with the VDI [ρ = -0.10 (95% CI 0.22, 0.03)]. The inter-observer reliability was very high with an intra-class correlation coefficient (ICC) of 0.996 (95% CI 0.990, 0.998) for the total BVAS v. 3 score. Conclusion. The BVAS v. 3 has been evaluated in a large cohort of patients with vasculitis and the important properties of the tool revalidated. This study increases the utility of the BVAS v. 3 in different populations of patients with systemic vasculitis.
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Mukhtyar, Chetan
(author)
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Flossmann, Oliver
(author)
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Alberici, Federico
(author)
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Baslund, Bo
(author)
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Batra, Rajbir
(author)
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Brown, Denise
(author)
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Holle, Julia
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Hruskova, Zdenka
(author)
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Jayne, David R W
(author)
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Judge, Andrew
(author)
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Little, Mark A
(author)
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Palmisano, Alessandra
(author)
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Stegeman, Coen
(author)
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Tesar, Vladimir
(author)
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Vaglio, Augusto
(author)
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Westman, KerstinLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)njur-kwe
(author)
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Luqmani, Raashid
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NjurmedicinSektion II
(creator_code:org_t)
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In:Rheumatology (Oxford, England): Oxford University Press (OUP)50, s. 899-9051462-03321462-0324
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Suppiah, Ravi
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Mukhtyar, Chetan
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Flossmann, Olive ...
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Alberici, Federi ...
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Baslund, Bo
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Batra, Rajbir
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Brown, Denise
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Holle, Julia
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Hruskova, Zdenka
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Jayne, David R W
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Judge, Andrew
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Little, Mark A
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Palmisano, Aless ...
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Stegeman, Coen
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Tesar, Vladimir
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Vaglio, Augusto
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Westman, Kerstin
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Luqmani, Raashid
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