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Clonal alteration o...
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Karlsson, E.Department of Oncology-Pathology, Radiumhemmet, Cancer Center Karolinska, Karolinska Institutet and University Hospital, Stockholm, Sweden
(author)
Clonal alteration of breast cancer receptors between primary ductal carcinoma in situ (DCIS) and corresponding local events
- Article/chapterEnglish2014
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LIBRIS-ID:oai:lup.lub.lu.se:6e30f6cc-fb73-4e61-aa6f-b5b04bf32548
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https://lup.lub.lu.se/record/4318529URI
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https://doi.org/10.1016/j.ejca.2013.10.020DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-215820URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-33747URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128154302URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcinoma in situ (DCIS) and intra-individually matched ipsilateral event. Materials and methods: The cohort includes 1504 patients, diagnosed with a primary DCIS between 1986 and 2004. Of the 274 patients who developed a local relapse, 135 developed a new in situ carcinoma and 139 an invasive cancer up to 31st December 2011. ER and PR were identified by immunohistochemistry (IHC) and HER2 by silver-enhanced in situ hybridisation (SISH) as well as IHC. Results: ER (n = 112), PR (n = 113) and HER2 (n = 114) status from both the primary DCIS and the corresponding relapse were assessed and were demonstrated to be discordant in 15.1%, 29.2% and 10.5% respectively. The receptor conversion was both from negative to positive and from positive to negative with no general pattern being seen in spite of sub-dividing into in situ relapse and invasive relapse. However, primary DCIS was HER2 positive in 40.3% whereas in situ and invasive relapses were HER2 positive in 42.9% and 34.5% respectively. Conclusions: Receptor conversion for ER, PR and HER2 status occurred between primary DCIS and corresponding local relapse in 10-30%. This study could not confirm that HER2 overexpression in primary DCIS had any impact on tumour progression to invasive cancer which has been proposed. (C) 2013 Elsevier Ltd. All rights reserved.
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Sandelin, K.Karolinska Institutet
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Appelgren, Jari,1973-Karlstads universitet,Avdelningen för nationalekonomi och statistik(Swepub:kau)jariappe
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Zhou, WeiUppsala universitet,Farmakologi(Swepub:uu)weizh111
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden(Swepub:lu)pat-kji
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Bergh, J.Karolinska Institutet
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Wärnberg, FredrikUppsala universitet,Institutionen för kirurgiska vetenskaper,Department of Surgery, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)fredwarn
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Zhou, WenjingDepartment of Surgery, Uppsala University, Uppsala, Sweden
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Karolinska InstitutetDepartment of Oncology-Pathology, Radiumhemmet, Cancer Center Karolinska, Karolinska Institutet and University Hospital, Stockholm, Sweden
(creator_code:org_t)
Related titles
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In:European Journal of Cancer: Elsevier BV50:3, s. 517-5241879-08520959-8049
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